This work shows that novel virus-like mesopore silica-zinc oxide/Ag nanoparticles (SZnOAg) synthesized and professionally collected on NIR laser irradiation with quercetin to improve their effectively eliminates the virus as a biomedical application. The properties of the nanoparticles can be tuned with respect to their core diameter, tubular length, and outer diameter. Due to their biomimetic appearance, they can rapidly transform living cells into virus-like particles, this SZnOAg nanomaterials has specific elimination effect on bacteriophage and covid-19. Using epitaxial growth, we can construct virus-like structures that can be used for biomedicine applications. These nanomaterials and NIR laser could open the way to a new range of antiviral materials, due to the low-efficiency cellular uptake of current nanoparticles, their applications in the biomedical field are limited. Herein, it clearly shown that novel mesoporous silica nanoparticles can be easily exhibited superior cellular uptake property.

The rationale of the current investigation was to develop a microemulsion based gel in the treatment of Psoriasis. The study consisted of Preformulation studies, Analytical method development studies, Formulation and characterization studies, Drug release studies and stability study. On the basis of results of solubility studies in different oils, surfactants and co-surfactants, tween 20 used as surfactant, IPA as co-surfactant and limonene as oil were chosen for the study. Pseudo ternary phase diagrams in different ratios of oils, S mix and water were developed, and 3:1 is suitable for preparation of MBG. On the basis of transparency, centrifugation, pH, globule size, zeta potential, polydispersity index, conductivity, thermodynamic stability, TEM, Dye solubility test and dilution test, formulation ME 2 batch was selected as an optimized formulation for designing Microemulsion. The pH of the formulations was found to vary between 6.26 and 6.79, a near neutral range which is ideal for topical applications. The Transmission electron microscopy of dimethyl fumarate loaded microemulsion showed a nanosized (70.31 nm) and spherical shape. The optimized batch has (-11.1) mV zeta potential, which indicates stable Microemulsion. From the stability study, we conclude that none of the Microemulsion systems showed signs of phase separation on centrifugation and freeze thaw cycle, so we conclude that the optimized batch was robust enough. The optimised ME 2 batch of dimethyl fumarate microemulsion was further incorporated in gel using aloe vera as moisturizing agent, carbopol as gelling agent. The pH of MBG was acceptable for the topical delivery system.

In recent time Club is become a main place of crimes like rape, murder, robbery, etc in metro cities. These types of social crimes are done mostly by using the newly invented medicines. Club crimes are type of assaults where the victim and the offender are in, or have been in, some form of personal social relationship, ranging from a first get together to an established relationship. Club drugs can incapacitate a person for a period of time and cause memory loss. These drugs may be colorless and odorless; their taste is easily masked. They may be in liquid form or dissolve easily in liquid. After ingestion, effects can occur immediately or within 15 to 30 minutes. The drugs described here are often called “date rape drugs” because they quickly increase a person’s vulnerability to sexual assault

Inflammation, oxidation, and compromised immunity all increase the dangers of COVID-19, whereas many pharmaceutical protocols may lead to increased immunity such as ingesting from sources containing vitamin E and zinc. A global search for natural remedies to fight COVID-19 has emerged, to assist in the treatment of this infamous coronavirus. Nigella satvia is a world-renowned plant, an esteemed herbal remedy, which can be used as a liquid medicine to increase immunity while decreasing the dangers of acute respiratory distress syndrome. Thymoqinone (TQ), dithymoqinone (DTQ) and thymohydroquinone (THQ), are major compounds of the essential oil contained in N. sativa. A current study aims to discover the antiviral activity of two compounds, Thymohydroquinone and Dithymoquinone, which are synthesized through simple chemical procedures, deriving from thymoquinone, which happens to be a major compound of Nigella sativa. A half-maximal cytotoxic con-centration, “CC50”, was calculated by MTT assay for each individual drug, The sample showed anti-SARS-CoV-2 activity at non-cytotoxic nanomolar concentrations in vitro with a low selectivity index (CC50/IC50 = 31.74/23.15 = 1.4), whereby Dimthymoquinone shows high cytotoxicity.

A rapid and sensitive high-performance liquid chromatography (HPLC) method was developed and validated in human plasma for simultaneous determination of rosuvastatin and candesartan, using atorvastatin as internal standard. Chromatographic separation was achieved on a Waters C18 column (250 × 4.6 mm, 5 µm). A response surface methodology based 3 2 full factorial design was employed to optimize critical chromatographic conditions viz. pH and composition of mobile phase for achieving good resolution between the desired analytes.