Dr. T. Panneerselvam working as a Professor cum Director R&D, Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy. He has 15 years of teaching and research experience with the credential of 24 patents, 01 textbook 21 research books and 85 scientific research articles with impact in international and national journals
Abstract
Adipocytes was investigated in the following study. The thiazole and its derivatives were found to have a wide range of biological actions, including anti-diabetic efficacy. Various spectral analyzers were used to assess the synthesized analogs, and the findings of the characterizations were used to corroborate the properties of the synthesized analogs.Methodology: The mechanism underpinning that the glucose utilisation of thiazole derivatives was investigated using molecular docking with the chosen target, and in silico studies revealed a robust interaction between thiazole derivatives and AMPK binding sites. The synthesized thiazole analogs were tested for their in vitro cellular viability and glucose uptake on 3T3-L1 adipocytes based on the significant report of in silico screening.
