Sergey Suchkov graduated from Astrakhan State Medical University and awarded with MD, then in 1985 maintained his PhD at the I.M. Sechenov Moscow Medical Academy and in 2001, maintained his Doctorship Degree at the Nat Inst of Immunology, Russia. From 1987 through 1989, he was a senior Researcher, Koltzov Inst of Developmental Biology. From 1989 through 1995, he was a Head of the Lab of Clinical Immunology IKI.
Abstract
Abs against myelin basic protein/MBP endowing with proteolytic activity) are of great value to monitor demyelination to illustrate the evolution of multiple sclerosis. Anti-MBP autoAbs from MS patients and mice with EAE exhibited specific proteolytic cleavage of MBP which, in turn, markedly differed between: MS patients and healthy controls. different clinical MS courses. EDSS scales of demyelination to correlate with the disability of MS patients to predict the transformation prior to changes of the clinical course.Ab-mediated proteolysis of MBP was shown to be sequence-specific whilst demonstrating fivesites of preferential proteolysis to be located within the immunodominant regions of MBP and tofall inside into 5 sequences fixed.
