SCIENTIFIC SESSIONS:

1.Metabolomics in Precision Medicine

Precision medicine is an approach to manage finding exact solutions to fathom the natural reason of infection. Precision medicine is a rising methodology for illness treatment. Accuracy offers cutting edge answers for augment your achievement in translational examination. Pharmacometabolomic, an emerging field in metabolomics, plays a key role in precision medicine.

2.Metabolic Modelling

Metabolic modelling allows a deep insight into the molecular mechanisms of a particular organism. A reconstruction process breaks down metabolic pathways into their respective reactions and enzymes, and analyses them within the perspective of the entire network. It collects all the relevant metabolic information of an organism and compiles it in a mathematical model. A deep analysis of these reconstructed pathways can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This information can then be applied to create novel biotechnological methods.

3.Clinical Metabolomics

Conventional biological diagnostic procedures are based on a time-consuming series of sequential biochemical tests. The rise of “omic” technologies offers the complete picture of basic molecules that build a biological system at different levels. Metabolomics is the most recent “omic” technology based on biochemical characterization of metabolites and their changes pertaining to genetic and environmental factors. Metabolomics, when used as a translational research tool, can offer a link between the laboratory and clinic, and produce results in a lesser time.

4.Plant Metabolomics

Metabolomics is the examination of endogenous and exogenous low atomic mass metabolites inside of a cell, tissue, or biofluid of a life form in light of an outer stressor. Plant Metabolomics is to contemplate the plant framework at the sub-atomic level giving complete characterization of metabolome of plants under particular conditions. Using Metabolomics, a better understanding of the correlation between genes and the biochemical composition of a plant tissue in response to its environment can be obtained, and this information can be further used to assess gene function.

5.Enzymology & Thermodynamics

In the presence of an enzyme, the reaction runs in the same direction as it would without the enzyme, just more quickly. For example, in carbonic anhydrase catalyses its reaction is either direction depending on the concentration of its reactants. The rate of a reaction is dependent on the activation energy needed to form the transition state which then decays into products. Enzymes increase reaction rates by lowering the energy of the transition state. First, binding forms a low energy enzyme-substrate complex (ES). Secondly the enzyme stabilises the transition state such that it requires less energy to achieve compared to the un catalyzed reaction (ES‡). Finally the enzyme-product complex (EP) dissociates to release the products.

6.Enzyme Kinetics

Enzyme kinetics is the study of the chemical reactions that are catalysed by enzymes. In enzyme kinetics, the reaction rate is measured and the effects of varying the conditions of the reaction are investigated. Studying an enzyme's kinetics in this way can reveal the catalytic mechanism of this enzyme, its role in metabolism, how its activity is controlled, and how a drug or an agonist might inhibit the enzyme.

7.Industrial Applications of Enzymology

Enzymes are used in the chemical industry and other industrial applications when extremely specific catalysts are required. Enzymes in general are limited in the number of reactions they have evolved to catalyse and also by their lack of stability in organic solvents and at high temperatures. As a consequence, protein engineering is an active area of research and involves attempts to create new enzymes with novel properties, either through rational design or in vitro evolution. These efforts have begun to be successful, and a few enzymes have now been designed "from scratch" to catalyse reactions that do not occur in nature. Enzymes are usually protein molecules that manipulate other molecules — the enzymes substrates. These target molecules bind to an enzyme's active site and are transformed into products through a series of steps known as the enzymatic mechanism.

8.Molecular Enzymology

Molecular enzymology is designing and synthesis of enzymes and high unmet medical needs are based on innovative drug targets. The work of designing and synthesis of enzymes and high unmet medical need are based on innovative drug targets.

Molecular Enzymology's interest include in all aspects related to enzymes like discovery of enzymes, enzyme structure, enzyme mechanisms, cellular and metabolic functions of enzymes, exploitation of enzymes for biotechnological and pharmaceutical applications, drug discovery, biochemical aspects of enzymes, bioinformatics, computational analysis, molecular modelling studies, new methods in enzyme expression and purification, bio catalysis, bio molecular engineering, enzyme kinetics and inhibitors.

9.Clinical Enzymology

Enzymes are catalysts that increase the rate or velocity of physiologic reactions. Each and every reaction in our body takes place with the help of an enzyme. In general, most enzymes are present in cells at much higher concentrations than in plasma. Measurement of their levels in plasma indicates whether their tissue of origin is damaged leading to the release of intracellular components into the blood. This forms the basis of clinical enzymology. Thus, clinical enzymology refers to measurement of enzyme activity for the diagnosis and treatment of diseases.

10.Enzymology in Food Processing & Technology

Food enzymology covers basic and applied aspects of the enzymology important to food systems. The basic aspects of the course include: methods of measuring enzymatic activities; extraction of enzymes from microbial, plant and animal systems; methods of enzyme purification and characterization; and regulation of enzyme activities by activators, inhibitors, and by covalent modification. Applied aspects of the course focus on enzymes used by the food industry and methods for controlling endogenous enzyme activities. Students develop novel food concepts based on enzymatic reactions/processes.

11.Genetics and Molecular Biology

Recombinant DNA technology involves joining together of DNA molecules to produce some new genetic combinations by inserting it into a host organism. Now a days Scientists are carrying out many novel researches in the field of recombinant DNA technology to bring revolution in the field of genetic engineering of crops, animals and medicine.

12.Metabolic syndrome

Metabolic syndrome is a cluster of physiological, biochemical, clinical, and metabolic factors that directly accelerates the risk of cardiovascular disease and diabetes mellitus. Insulin resistance, visceral adiposity, atherogenic dyslipidemia, endothelial dysfunction, genetic susceptibility, elevated blood pressure, hypercoagulable state, and chronic stress are the several factors which constitute the syndrome. Lifestyle modification remains the initial intervention of choice for such disorders. Modern lifestyle modification therapy combines specific recommendations on diet and exercise with behavioural strategies. The pharmacological and metabolomic data helps in overcoming such problems.

MARKET ANALYSIS:

‘The Future of Metabolomics' gives complete understanding into the compelling utilization of metabolomics all through drug discovery, preclinical development and clinical trials. The report also highlights the use of metabolomics in maximizing and sustaining revenues post-marketing and in the development of clinical diagnostics.

Scope & Importance:

The emerging techniques of metabolomics make it an ideal tool for new innovations in the pharmaceutical, preventive healthcare, and agricultural industries. Discovery of Biomarkers and drug safety screens are two examples where metabolomics has already proven its mark. In the future, with the accessibility of personalised metabolomics, we will potentially be able to track the trends of our own metabolome for personalised precision drugs and improved treatment strategies. Personalised precision treatment is likely to be more effective than our current medical approaches.

Metabolomics is now being extensively used in pharmaceutical and biotechnology industries for biomarker and drug discovery; pharmaceutical and biotechnology industries are expected to grow at a high rate in coming years, which is expected to boost the growth of the market.

The National Institutes of Health(NIH) grants funds to Metabolomics program. This aims to elevate national capacity in metabolomics by supporting the development of next generation technologies to enhance the sensitivity and speed with which specific elements of the cellular metabolome can be identified and quantified, providing opportunities, rising the inventions of chemically identifiable metabolites through the synthesis and availability of high quality reference standards, and by promoting data sharing and collaboration.

Rise in the number of clinical trials, toxicological studies, and health awareness for nutritional products, rapid growth of metabolomics data analysis software and solutions, and use of metabolomics as diagnostic tool for biomarker, screening of diseases is expected to propel the growth of this market.

Why to attend?

Meet your target market with recent business reports on Metabolomics which manifests the tremendous growth in market value for metabolomics technology till 2019. Since metabolomics interrelated with omics sciences like Genomics, precision Medicine, Proteomics, Lipidomics and Transcriptomics, it would be a great opportunity for companies dealing with Analytical instruments useful in these fields. Also, many upcoming students and researchers can benefit themselves by participating world class International workshops, symposia during the conference which will be conducted by experts in their respective fields.

Target Audience:

Metabolomics Instrumentation Technology Product Manufacturers
Researchers and Scientists
Metabolomics Industry Consulting Firms
Metabolomics Research and Development (R&D) Companies
Healthcare Institutions
Research Institutes
Market Research and Consulting Firms
Directors/Managers & Business Delegates,
Director of Laboratories, Universities,
Investigators,
Post-Doctoral Fellows,
Students,
Biomedical Research companies

Glance at Market of Metabolomics:

The market is mainly driven by the increasing research funding for metabolomics from governments and private investors, growing demand for personalized medicine in the U.S. and Europe, and the increasing need for toxicology testing. However, low adoption rates and data complexity inhibits the growth of the metabolomics market to a certain extent. Metabolomics science is used extensively in biomarker discovery and drug assessment. Thus, the rapid growth experienced by pharmaceutical and biotechnology industries is assisting the growth of the metabolomics market.

In 2017, North America was the market leader with a share of ~42% of the global market, followed by Europe with a share of ~38%. The presence of large number of analytical equipment manufacturers has contributed significantly to the North American and European metabolomics market. The growth in this market is driven by the growing pharmaceutical and biotechnology industries.

The global metabolomics market was valued at $565 million in 2014, and $1030 million in 2016. and is expected to grow at a CAGR of 14.6% during the forecast period (2016–2021) to reach $2410 million by 2022.

Statistics of Industries Associated with Metabolomics:

North America was the market leader with a share of ~42% of the global market, followed by Europe with a share of ~38%. The presence of a large number of analytical equipment manufacturers has contributed significantly to the North American and European metabolomics market. However, the Asia-Pacific region represents a significant growth opportunity for the metabolomics market during the forecast period of 2014 to 2019. The APAC market is expected to grow at a CAGR of 23% during the forecast period. The growth in this market is driven by the growing pharmaceutical and biotechnology industries.

The major players in the metabolomics market include Thermo Fisher Scientific (U.S.), Metabolon, Inc. (U.S.), Danaher Corporation (U.S.), Shimadzu Corporation (Japan), Waters Corporation (U.S.), Agilent Technologies (U.S.), and Bruker Corporation (U.S.)

Fund Allotment towards Metabolomics Research:

The National Institutes of Health has provided tens of millions of dollars in new funding to support three new Comprehensive Metabolomics Centers at Mayo Clinic, the University of Kentucky, and the University of Florida.

These three centers will receive an estimated $9 million to $10 million each over the next five years to create resources and initiate research programs that will ramp up the national metabolomics science capabilities.

NIH provided $14.3 million to fund the launch of three other metabolomics resource centers at the University of Michigan, the Research Triangle Institute, and the University of California, USA.

Funding to UC San Diego for this project is $6 million over five years, part of a total investment by the NIH of $51.4 for the metabolomics project. The awards are supported by the NIH Common Fund Mayo Clinic is one of six new federally-funded Comprehensive Metabolomics centres to support medical research on metabolomics — the study, at the cellular level, of how molecules are metabolized in the body. The award from the National Institutes of Health (NIH) is for $8.8 million over five years.

Major Metabolomics Related Associations across the Globe:

American association for the advancement of science
American association for clinical chemistry
American association for cancer research
American association of pharmaceutical scientists
American cancer society
Bioinformatics society of India
Nutrigenomics Organization
The British Society for Genetic Medicine
The Genetics Society
Netherlands metabolomics center
The Australian biotechnology association
Human Proteome Organization
Indiana Proteomics Consortium
Proteome Society
European federation of biotechnology
Australasian Proteomics Society
Clinical Genetics Society

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