Yuan Xiong joined Certara Strategic Consulting in 2016 as Associate Director, Consulting Services. With 10 years of experience in pharmaceutical R&D, Dr. Xiong has in-depth hands-on experience of population PK/PD modeling, clinical trial simulations, and systems pharmacology in therapeutic areas such as infectious diseases, autoimmune disorders, ophthalmology, cardiovascular and metabolic diseases, neuroscience and oncology. Additionally, Dr. Xiong has strong research & development experience in mathematical modeling of complex biological and physiological systems, disease models, cell signaling pathways, stochastic simulations, and biomedical image processing and analysis; proficient in MATLAB, PhysioLab, SBPOP2, and COMSOL Multiphysics, and familiar with C/C++, Mathematica, and Linux. Dr. Xiong received her PhD in electrical and computer engineering from The Johns Hopkins University. She has published many papers in the past ten years, collaborating and communicating experience working in multi-disciplinary teams of quantitative and computational scientists, clinicians and life scientists.
The treatment of diabetic wounds remains one of the major challenges in clinical practice, due to the multiple drug-resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment. Herein, we sought to introduce a novel in-situ injectable HA@MnO2 hydrogel to accelerate the diabetic wound healing. Through the convenient injection, this hydrogel can form a protective dressing covering the wound to provide rapid haemostasis and long-term antibacterial. Meanwhile, the MnO2/ e-PL nanosheet catalyze the overexpressed H2O2 in wound to convert to O2, so that eliminating the harmful effect of H2O2 and providing enough O2 for wound healing. Moreover, the following releasing of M2-derived Exosome (M2 Exo) and FGF-2 growth factor constantly simulate the angiogenesis and epithelization, respectively. . The in vivo and in vitro results determined an accelerated diabetic wound healing using HA@MnO2 hydrogel, which representing a versatile strategy for repairing a wide range of diabetic tissue damages.
Background:
Traditional plaster (TP) is a widely used auxiliary fixation (AF) approach for postoperative fracture patients. However, patient discomfort and inconvenience to clinicians has limited its application. We introduce a novel instant 3-dimensional printing appliance system (3D-AS) to address such issues.
Material/Methods:
Twenty-seven postoperative fracture patients were divided randomly between a TP group and a 3D-AS group, and analyzed retrospectively. Radiographic images during follow-up were evaluated for fracture healing and fracture reduction quality. The range of motion (ROM) was recorded to assess motor performance. Patient pain was assessed using the Visual Analogue Scale (VAS). Complications were also compared between the 2 groups.
Results:
The patients comprised 17 men and 10 women with ages ranging from 21 to 69 years (mean age: 47.35). All patients completed a follow-up visit (range: 14–19 months, mean: 13.59 months). Although no significant difference was found between general characteristics (P>0.05) and the time of fracture union (P>0.05), significant
differences between groups were seen in complications (P<0.05), VAS (P<0.01), patient satisfaction (P<0.05), and ROM for the upper joints (P<0.05).
Conclusions:
Our study suggests that 3D-AS provides better upper-limb ROM and more comfortable healing for postoperative fracture patients, indicating that it can be recommended for use in such patients.