Title: Nanoenzyme-Reinforced Injectable Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed-release of Exosome and Fibroblast Growth Factor

Biography:

Yuan Xiong joined Certara Strategic Consulting in 2016 as Associate Director, Consulting Services. With 10 years of experience in pharmaceutical R&D, Dr. Xiong has in-depth hands-on experience of population PK/PD modeling, clinical trial simulations, and systems pharmacology in therapeutic areas such as infectious diseases, autoimmune disorders, ophthalmology, cardiovascular and metabolic diseases, neuroscience and oncology. Additionally, Dr. Xiong has strong research & development experience in mathematical modeling of complex biological and physiological systems, disease models, cell signaling pathways, stochastic simulations, and biomedical image processing and analysis; proficient in MATLAB, PhysioLab, SBPOP2, and COMSOL Multiphysics, and familiar with C/C++, Mathematica, and Linux. Dr. Xiong received her PhD in electrical and computer engineering from The Johns Hopkins University. She has published many papers in the past ten years, collaborating and communicating experience working in multi-disciplinary teams of quantitative and computational scientists, clinicians and life scientists.

Abstract

The treatment of diabetic wounds remains one of the major challenges in clinical practice, due to the multiple drug-resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment. Herein, we sought to introduce a novel in-situ injectable HA@MnO₂ hydrogel to accelerate the diabetic wound healing. Through the convenient injection, this hydrogel can form a protective dressing covering the wound to provide rapid haemostasis and long-term antibacterial. Meanwhile, the MnO₂/ e-PL nanosheet catalyze the overexpressed H₂O₂ in wound to convert to O₂, so that eliminating the harmful effect of H₂O₂ and providing enough O₂ for wound healing. Moreover, the following releasing of M2-derived Exosome (M2 Exo) and FGF-2 growth factor constantly simulate the angiogenesis and epithelization, respectively. . The in vivo and in vitro results determined an accelerated diabetic wound healing using HA@MnO₂ hydrogel, which representing a versatile strategy for repairing a wide range of diabetic tissue damages.