18th International Conference on
Pharmaceutics & Novel Drug Delivery Systems
Scientific Program
Keynote Session:
Title: Plasmonic nanostructures for imaging and targeting drug delivery
Biography:
Oara Neumann is the Peter M. and Ruth L. Nicholas Research Scientist at Rice University. She has completed her PhD and Postdoctoral study in Applied Physics at Rice University, and MSc in Chemical Physics from Weizmann Institute of Science, Israel and also MSc in Analytical Chemistry from Bucharest University, Romania. She is the pioneer of nanoparticle-based solar thermal applications. She holds several patents and she has published more than 24 refereed articles and has an h-index of 16.
Abstract:
Engineering a compact, near-infrared plasmonic nanostructure with integrated image-enhancing agents for combined imaging and therapy is an important nanomedical challenge. To overcome this challenge we designed a nanostructure with NIR plasmonic signatures composed of a 50 nm Au core surrounded a SiO2 inner-shell doped with contrast agents and an outer Au shell. The plasmon resonance of this nanostructure, known as a nanomatryoshka (NM), can be tuned to the desired wavelength by varying the thickness of the layers. The encapsulated contrast agents used in this study are: Fe(III)-DOTA, Gd(III)-DOTA, and fluorescent dyes. The Fe(III)-NM based contrast agents are found to have relaxivities two times greater than the widely used Gd(III)-DOTA, providing a practical alternative for T1 MRI contrast agent that eliminates Gd(III) patient exposure entirely. Additionally, the internalization of fluorescent dyes and MRI contrast imaging agents within the NM substantially reduces the toxicity while maintaining a free nanoparticles surface for further bio-functionalization.
Title: Dendrimer nanotechnology for personalized nanomedicine
Biography:
Ling Peng is a leading expert in developing functional dendrimer nanosystems for drug delivery in biomedical applications. She has successfully established bio-inspired structurally flexible and self-assembling dendrimer nanosystems for drug and nucleic acid delivery. She is currently a research director at the French National Scientific Research Center (CNRS), and a principle investigator at the Centre Interdisciplinaire de Nanoscience de Marseille (CINaM).
Abstract:
Nanotechnology is widely expected to bring breakthroughs in specific delivery of the right therapeutic agent to the right patient at the right disease. Dendrimers are ideal nanocarriers for drug delivery by virtue of their uniquely well-defined structures and multivalent cooperativity confined within a nanosized volume. We have established bioinspired structurally flexible and self- assembling supramolecular dendrimers for drug delivery. These dendrimers are excellent nanocarriers for personalized medicine. They are able to form modular, responsive and adaptive nanosystems, and effectively deliver various chemo- and bio-therapeutics as well as imaging agents for precise diagnosis and personalized treatment in various disease’s models. These studies have offered new perspectives in dendrimer nanotechnology based biomedical applications.
Oral Session 1:
- Pharmaceutics | Drug Delivery Techniques | Nano-medicine and Nano Technology
Title: Molecule of millennium - Taurine; & its analogues: A new class of therapeutics in human welfare
Biography:
Ramesh Gupta is vice chancellor of Radha Govind University, India and is former Pro Vice Chancellor of Nagaland Central university India, had obtained PhD as the age of 23 years. Ramesh Gupta is a Medicinal & Bioorganic Chemist and has worked for several years as a visiting Professor/Scientist in various medical schools; Louis Pasture University, France; University of Arizona, USA; Osaka University & Nagoya University, Japan.
Abstract:
Chemicals are not single minded, in differ environment they me be friend or foe. Human body is reservoir of a large number of molecules with diverse nature of chemical identities influencing the mind and mood. Amino acids constitute a large portion with such agents; one of such agent is Taurine (2-Amino Ethane Sulfonic Acid). Its content is high in several human tissues like, heart, brain, liver, kidney and eye. Taurine is 0.1 % of total body weight amounting 70 g in a normal human of 70 kg. It has beneficial actions in epilepsy, hypertension, congestive heart failure, liver & eye and in some others. Its preventing role is increasing in various life threaten diseases. Bone loss in women is an age old problem where it has helping hand. It has been patented for several symptoms and diseases and found to have clinical utility. But being an amino acid, therapeutic use confronts limitations; restricted permeability, higher doses and many more; necessitate to relook for the development of pro-drugs (analogues) of taurine exploiting various structural alterations in carbon chain, amino and sulfonic ends. A large number of taurine derivatives have been reported with partial to marked activity. Taurine derivatives like taltarimide, acomprosate and tauromustine are already in use as anticonvulsant, anti-alcoholic and anti cancer agents. Taurine is now part of several energy drinks, functional food, nutriceuticals, and anti-ageing formulas. The in depth analysis of these analogues and their biological actions can provide certain clues for further consideration. In presentation attempts have been made to provide synopsis, synthesis and symbiosis of its chemical and biological actions, which may facilitate further research in this area. The successful journey of these heterocycles to clinical utility is a healthy and happy sign and an index of bright future in alleviating such suffering.
Title: Protective role of ascorbic acid on subacute toxicity in rabbits treated with ivermectin: Biochemical and histopathological investigations
Biography:
Hassina Khaldoun Oularbi working as a Professor at Department of Biology in University of Blida 1, Algeria. Her research interest in Pharmaceutical, Medicinal and Organic Chemistry.
Abstract:
Ivermectin (IVM) is a lipophilic anthelmintic drugs widely used for the control of internal and external parasites in both clinical and veterinary medicine. The present experiment pertains to the protective role of ascorbic acid (AA) against biochemical and histopathological toxicity induced by subacute exposure to ivermectin in male young rabbits «Oryctolagus cuniculus». Twenty rabbits were divided into four groups of five. Control group and ivermectin treated groups subcutaneously with a high dose (2 mg kg−1 of body weight) of ivermectin (3 times/week) for three consecutive weeks, alone (IVM-group); or orally co-treated with ascorbic acid by gavage (group-IVM+AAg) (20 mg/kg/mL) or AA food supplemented (group-IVM+AAf) (200 mg/kg/food) respectively, with a mean interval of 24 h after IVM injection. During the experiment, ivermectin alone caused signs of toxicity (hair loss and diarrhea) and disruption of the kidney and liver biochemical parameters and lipid profile with statistically significant increase (p <0.05) in blood glucose and levels of liver enzymes (ALAT, ASAT and γ-GT) at day14 and day21. However, the co-administration of the ascorbic acid has moderately corrected and improved these biochemical parameters. Light microscopic observations revealed variable signs of brain, renal and hepatic toxicity in the IVM group alone. However, AA treatment showed significant amelioration when coupled orally with IVM. These findings suggested that AA has beneficial influences in neutralizing the sub-acute toxic effects of IVM in the biochemical parameters and histology of liver, kidney and brain of rabbits.
