Haya A Abubshait , worked at department of chemistry, teaching undergraduate courses for medical college and health trach, I am interested in multidisciplinary research , like Nano-synthesis of pharmaceuticals compounds, Computational chemistry Microbiology Pharmaceutical Chemistry Organic Chemistry, synthesis, mechanism, spectroscopy
Abstract
Benzopyrano [4,3-d]-pyrimidine Derivatives (3a-c and 4) were prepared via cyclocondensation of 3-ethoxycarbonyl coumarin derivatives (2a-c) with guanidine hydrochloride and thiourea under reflux. Acetylation of (3b, c) with acetic anhydride provided N-acetyl derivatives (5a, b) of benzopyrano-imidazolo-[2,1-a]-benzopyrano [4,3-d]-pyrimidin-1, 6-dione (6) was obtained by treatment of 2-amino-benzopyrano [4, 3-d]-pyrimidine with ethylchloroacetate. Structures of these compounds were established on basis of IR, 1H-NMR and MS data. Some of the prepared compounds were evaluated for antimicrobial and antitumor activities.
