Title: Urine is an early sensitive biomarker source for many systematic diseases

Biography:

Youhe Gao is the Professor Beijing Normal University. He received his MD from Peking Union Medical College, his PhD from University of Connecticut and postdoctoral training from Beth Israel Deaconess Medical Center, Harvard Medical School. He was the Professor of Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/ Peking Union Medical College from 2001-2014. His research interests include biomarker discovery in urine, urine biobanking, protein interaction methods and related bioinformatics.

Abstract

Statement of the Problem: How to find the early sensitive biomarker is the most important question for medicine. Theoretical Orientation: Biomarker is the measurable change associated with the disease. Without homeostatic control, urine accumulates many early changes therefore theoretically is a better biomarker source than blood. Findings: Disease animal models were used to limit the confounding factors to the minimum. Early candidate biomarkers were found in many disease models including type2 diabetes, lung fibrosis, liver fibrosis, chronic pancreatitis, chronic obstructive pulmonary disease, multiple sclerosis, myocarditis, subcutaneous cancer model, bacterial meningitis, astrocytoma cancer model, patient-derived xenograph model, Alzheimer disease etc. Relatively significant percentage of those candidate biomarkers had been reported to related to the disease. And many early biomarkers appeared earlier than the clinical symptom, than MRI imaging, than significant pathological changes. Preservation of urine samples on the membrane will also be discussed. This simple and economical method will greatly speed up the urinary biomarker discovery and validation. Conclusion & Significance: Urine is an early sensitive biomarker source for many systematic diseases.