Be a part of 10^th International Conference on Tissue Engineering & Regenerative Medicine

The therapeutic materials used for tissue engineering must not be toxic to the human biological system. These materials contains therapeutic agents and bioactive molecules which promotes tissue repair, it also provides tailored mechanical support, bone and tissue regeneration and many are also designed to encourage a controlled drug release, thus ensuring the therapeutic drug remains in the system for longer. The materials commonly used for these process includes biodegradable and bioactive polymers, ceramics and composites.

It is a novel field of therapeutic technique wherein personalized prescriptions or medications are provided to an individual. Pharmacogenomics and cellular therapy comprises together for the development of personalized therapy. The basis of regenerative medicines lies on the various forms of stems cells like, mesenchymal stem cells, pluripotent stem cells and embryonic stem cells which has a property of indefinite regeneration. Among the above mentioned the pluripotent stem cells are found to be a suitable candidate for personalized medicine.

Biodegradability and biocompatibility are the most important features for a scaffold to be used in tissue engineering. The materials should contain sufficient porosity, a proper architecture and an adequate pore size are necessary to facilitate cell seeding and diffusion throughout the whole structure of both dividing cells and nutrients. Scaffolds are of excessive importance in clinical medicine, it is a forthcoming field and typically related with conditions involving organ disease or failure.

The progressive evolution of bioengineered materials has led to a versatile field of study and has increased their utility for therapeutic purpose.  Biomaterials have revolutionized the areas like bioengineering and tissue engineering for the development of novel approach to combat life threatening diseases. Together with biomaterials, stem cell technology is also mostly used to improve the existing healthcare facilities.

Medicine based on the application of the principles of the natural sciences and especially biology and biochemistry and the medical drugs produced using biotechnology process. It including proteins (antibodies), nucleic acids (DNA, RNA or antisense oligonucleotides) used for therapeutic or in vivo diagnostic purposes, and are produced by means other than direct extraction from a native (non-engineered) biological source.

The tissue engineering technology has cantered on bone graft substitute for the engineering of mucoskeletal tissues, such as bone and cartilages. The primary concern of these substitutes to be used in bone grafting is biodegrability of the scaffolds. Currently tissue engineering strategies have included cell and gene therapy. Tissue engineering of musculoskeletal tissues is a rapid developing field. The availability of growth factors and the expanding knowledge base concerning the genetics and regulation of bone formation have developed new materials for tissue-engineering applications.

The skin is the largest organ of the human body which serves as a protecting barrier to the environment and promotes hydration retention and thermal regulation. Extreme loss of skin may occur due to various forms of injury or illness which might result in an ample physiological imbalance and it leads to major disability or even death. Tissue-engineered skin (TES) alternates signify a logical beneficial option for the treatment of severe and all chronic skin injuries.

Tissue or engineered devices incorporated into the human body for replacement of a natural organ, interfacing with natural tissue are known as bioartificial organ. It combines biomaterials and biological cells for full replacement of patient failure organs. The commonly engineered bioartificial organs are bioartificial kidney devices, combining biomaterials and kidney epithelial cells for improved blood detoxification, bioartificial pancreas devices, combining encapsulation of pancreatic cells for treatment of diabetes, bioartificial lungs for studying lung regeneration.

The remarkable improvement in the field of stem cell research has set the foundation for cell based treatments of disease which cannot be cured by conventional medicines. The capability of self-renewal and segregate into other forms of cells signify stem cells as borderlines of regenerative medicine. Progresses in gene editing and tissue engineering machinery have permitted the ex vivo remodeling of stem cells grown into 3D organoids and tissue structures for personalized uses.

The idea that cancer is primarily driven by a smaller population of stem cells has important implications.  They can divide and renovate themselves for long periods and are capable of give rise to specialised cells. They can therefore summarize tumour heterogeneity as they can be found in tumours. Research so far has proposed they also have multi drug and radiotherapy resistance. Hence there may be more similarities between cancer stem cells and normal stem cells.

Tissue engineering represents one of the most exciting advances in regenerative medicine. Guide Tissue Regeneration is defined as the procedures of attempting to regenerate lost periodontal structures through differential tissue responses. It lays emphasize on the development of both hard tissue as well as soft tissues of the periodontal supplement. With the help of GTR, 3-dimensional tissues that accurately integrate with a patient's body are been produced.