Title: Greener synthesis of biological and pharmaceutical compounds

Biography:

Ahindra Nag is an Associate Professor of organic chemistry in Chemistry Department, Indian Institute of Technology, Kharagpur, India. He has got 32 years teaching and research experiences. He has published 80 journal papers, 10 text books and three patents. He has guided twelve students and was visiting Professor in different universities such as Taiwan (Academia sinica), Rome (Campobossa) and America (Tennessee, USA).

Abstract

β-amino alcohols and its derivatives are the versatile intermediates for synthesis of biologically active natural compounds. For ring opening of epoxides, several groups have been used various type of catalyst like lewis acids, metal salts, lanthanide halides, triflates, boranes, heterogeneous catalysis, ionic liquids and alumina. But we have synthesized these derivatives by synthesis of new type of epoxides by using this below mentioned synthetic route (Scheme 1) where ACC juice has been used1-4. Again, we are interested to synthesize biscoumarins and pyranocoumarins which have also biological and pharmaceutical applications. Biscoumarin and Bis indoyl methane which can be used to treat anaphylaxis, cardiac arrest and superficial bleeding has been synthesised using waste material (Scheme 2).

 

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Scheme 1

 

Scheme2