Title: Blau Syndrome: A Rare Granulomatous Disorder

Biography:

Gaurav Rajauria is an Assistant Professor by profession and works with one of the private university in Aligarh. He holds a doctor of pharmacy in Pharmacy and currently pursuing a Master in Public health degree in Indian institute of public health sciences, Gujarat. Gaurav has 1 years of research experience.

Abstract

Blau syndrome is a rare condition characterized by the triad of granulomatous skin lesions, symmetric polyarthritis with boggy joint swellings, and ocular inflmmation. It has an autosomal dominant mode of inheritance and occurs due to a mutation in CARD-15/NOD-2 gene which encodes the cytosolic NOD2 protein, a key molecule in the regulation of innate immunity. Clinical onset is generally in the 1 st year of life and is characterized by articular, cutaneous, and ocular noncaseating granulomatous inflmmation, which can be variably associated with a heterogeneous systemic spectrum.