A giant cell tumor of tendon sheath (GCTTS) is a benign

lesion whose presence in Hoffa’s pad has been rarely reported. In this case report we have demonstrated a case of GCTTS in a 37 year old female in Hoffa’s fat pad of knee. The patient had presented with the symptoms of pain and swelling in her left knee and provisionally diagnosed as ganglion cyst. The radiographic findings were inconclusive. The diagnosis was confirmed with excisional biopsy after the tumor was completely removed. This is a unique case report which shows

the presence of a large tumor (5×3×2 cm) in Hoffa’s fat pad

which was diagnosed as GCTTS and managed with openresection due to its size. Oxford knee score has improved

from 34 from the time of presentation to 58, six months post

surgery. The patient was pain free, had full range of motion

and had returned to previous level of activities and there was

no sign of any recurrence. Giant Cell Tumor should be kept

as a differential of non-traumatic chronic knee pain in young

individuals.