Date
April 16-17, 2025 | 09:30 AM GMT
Location
Tokyo, Japan
Tokyo, Japan
Huang Wei Ling, born in Taiwan, raised and graduated in medicine in Brazil, specialist in infectious and parasitic diseases, a General Practitioner and Parenteral and Enteral Medical Nutrition Therapist. Once in charge of the Hospital Infection Control Service of the City of Franca’s General Hospital, she was responsible for the control of all prescribed antimicrobial medication and received an award for the best paper presented at the Brazilian Hospital Infection Control Congress in 1998. Since 1997, she works with the approach and treatment of all chronic diseases in a holistic way, with treatment guided through the teachings of Traditional Chinese Medicine and Hippocrates. Researcher in the University of São Paulo, in the Ophthalmology department from 2012 to 2013.Author of the theory Constitutional Homeopathy of the Five Elements Based on Traditional Chinese Medicine. Author of more than 60 publications about treatment of variety of diseases rebalancing the internal energy using Hippocrates thoughts
Huang Wei Ling, born in Taiwan, raised and graduated in medicine in Brazil, specialist in infectious and parasitic diseases, a General Practitioner and Parenteral and Enteral Medical Nutrition Therapist. Once in charge of the Hospital Infection Control Service of the City of Franca’s General Hospital, she was responsible for the control of all prescribed antimicrobial medication and received an award for the best paper presented at the Brazilian Hospital Infection Control Congress in 1998. Since 1997, she works with the approach and treatment of all chronic diseases in a holistic way, with treatment guided through the teachings of Traditional Chinese Medicine and Hippocrates. Researcher in the University of São Paulo, in the Ophthalmology department from 2012 to 2013.Author of the theory Constitutional Homeopathy of the Five Elements Based on Traditional Chinese Medicine. Author of more than 60 publications about treatment of variety of diseases rebalancing the internal energy using Hippocrates thoughts
Kensuke Joh, Professor, Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan. Licensure in Medicine, Dissertation, Visiting Professor, Department of Pathology, Tohoku University Graduate School of Medicine. Current and previous research interests as clinicopathological study on IgA nephropathy. Councilor, Japanese Society of Pathology, Councilor, Japanese Society of Nephrology. Memberships of Renal Pathology Society, USA. My complete biography is available from my ORCID https://orcid.org/0000-0002-9334-3664
Tonsillectomy with steroid pulse therapy (SPT) has been established as an effective treatment for immunoglobulin A nephropathy (IgAN) in Japan. However, the underlying mechanisms supporting tonsillectomy remain unclear. This study assessed palatine tonsils from 77 patients with　IgAN, including 14 and 63 who received SPT before and after tonsillectomy, respectively. Tonsils from　21 patients with chronic tonsillitis were analyzed as controls. Specific tonsillar lesions were confirmed in patients with IgAN, correlating with active or chronic renal glomerular lesions and SPT. T-nodule and involution of lymphoepithelial symbiosis scores in tonsils correlated with the incidence of active crescents and segmental sclerosis in the glomeruli, respectively. The study revealed an essential role of the tonsil–glomerular axis in early active and late chronic phases. Moreover, the SPT-preceding group demonstrated no changes in the T-nodule score, which correlated with active crescent formation, but exhibited a considerable shrinkage of lymphatic follicles that produced aberrant IgA1. The study underscores the involvement of innate and cellular immunity in IgAN and advocates for tonsillectomy as a necessary treatment alongside SPT for IgAN, based on a stepwise process.
John Maesaka, professor of medicine at NYU Grossman Long Island School of Medicine and Chief Emeritus, Division of Nephrology and Hypertension at the NYU Langone Hospital Long Island. He received a BA degree Harvard University, MD degree Boston University School of Medicine and trained at Barnes Jewish Hospital Washington University in St. Louis and Mount Sinai Hospital and Medical School N.Y. He spent 5 years in a physiology laboratory at Mount Sinai Medical Center, which prepared him for his future research endeavors. He spent many years studying hyponatremic conditions, especially renal salt wasting and identifying the protein that causes it
Background: The approach to hyponatremia is in a state of flux. Cerebral/renal salt wasting (RSW) is considered rare and presents with identical parameters as SIADH that create a diagnostic and therapeutic dilemma, whether to fluid-restrict water-logged patients with SIADH or administer saline to dehydrated patients with RSW. We previously demonstrated the presence of a natriuretic protein (NP) in the plasma of RSW neurosurgical patients and in patients with Alzheimer’s disease (AD).
Methods: We determined the causes of hyponatremia in the general hospital wards by utilizing a new algorithm and identified the NP in an RSW patient with subarachnoid hemorrhage (SAH) and another with AD by the same rat clearance methodology.
Results: Of 62 hyponatremic patients, (A) 17 patients (27%) had SIADH, (B) 19 patients (31%) had a reset osmostat (RO), (C) 24 patients (38%) had RSW, 21 without clinical evidence of cerebral disease, (D) 1 had Addison’s disease and (E) 1(1.6%) due to hydrochlorothiazide.
The SAH and AD sera had identical robust increases in FEsodium and especially FElithium, lithium serving as a marker of proximal tubule sodium transport. We identified haptoglobin related protein (Hpr) without signal peptide (Hpr-WSP) as the natriuretic protein. Recombinant Hpr with signal peptide had no natriuretic activity.
Conclusions: RSW is common, cerebral salt wasting should be changed to renal salt wasting. Hpr-WSP may be the NF that causes C-RSW, can serve as a biomarker to differentiate RSW from SIADH on first encounter, need to develop inhibitor to HPR-WSP, introduces a new syndrome of RSW in AD and can effectively treat congestive heart failure when combined with distal diuretic.
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