Title: MANAGEMENT OF ENVENOMATION INDUCED AKI WITHINTERMITTENT HAEMODIALYSIS IN A DOG

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Abstract

A fourteen-month-old Labrador dog (BRUNO) was presented to the pet hospital with a recent history of viper envenomation. The dog was vocalising and restless. On the day of presentation, seem creation and blood nitrogen (BUN) values were 3.7mg/dL and 89.1 mg/dL respectively. The serum creatinine and blood urea nitrogen values elevated within two days to BRUNO IN PET HOSPITAL KOCHIN 6.7mg/dL and 138.6mg/dL respectively. The doy become oliguria. The clinical signs and laboratory values were consistent with acute kidney injury. Intermittent haemodialysis (IHD) was carried out as the dog was refractory to medical management. Post IHD creatinine and BUN values were 6.7 mg/dL and BUN Values 101 mg/dL, respectively. Serum creatinine and BUN value increased to 7 mg/dL and 130 mg/dL, the next day after IHD. The second session of IHDreduced serum creatinine and BUN values to 6 mg/dL and 97.8 mg/dL. The dog continued to be dull, and anorexic with oliguria. The third session of IHD helped in the reduction of serum creatinine and Oliguria resolved. The dog resumed his appetite and was clinically stable. The dog was observed for the next 24 hours and discharged. On review after three days, the dog exhibited considerable improvement; creatinine and BUN values were 3.1 mg/dL and 54.4 mg/dL, respectively. Ten days later follow-up revealed that creatinine and BUN values stabilised at 1 mg/dL and 24 mg/dL. The dog showed alow and steady recovery from acute kidney injury over a period of 20 days. Viper envenomation induces kidney injury (Hrovat et al 2013) Intermittent haemodialysis is a renal replacement therapy which is used to alleviate lifethreatening azotaemia electrolyte and acid-base imbalances and control intravascular volume (Cowgill) and Elliott, 2000). This article describes a case viper envenomation induced acute kidney injury in a dog, which was successfully managed with three sessions of intermittent haemodialysis.