Title: A novel research area of PCDH-PC in inhibition of prostate cancer cells invasion and metastasis through epithelial-mesenchymal transition

Biography:

Prof. Xuezhen Yang graduated from Peking University with a doctor’s degree in Surgery, studied under Professor Liqun Zhou and Academician Yinglu Guo. He have been studying in several world famous universities for 5 years and have rich clinical experience in the diagnosis and treatment of urinary system tumor. He is invited to give academic reports and won awards in international and domestic conferences for many times, and have served in many academic societies at home and abroad. Prof. Yang won one national and one provincial project, published many papers and participated in the translation and compilation of four monographs.

Abstract

Objective: To evaluate the effects of protocadherin-PC (PCDH-PC) gene expression on epithelial–mesenchymal transition (EMT) in prostate cancer cells. Methods: Western blot analysis, morphological analysis, and in vitro wound closure assay were used to assess the effects of inhibition of PCDH-PC expression on EMT in the androgen-independent prostate cancer cell lines DU-145 and PC-3. Results: Inhibition of PCDH-PC expression promoted mesenchymal–epithelial transition (MET) of DU-145 and PC-3 cells, which changed the cytomorphology to resemble that of the androgen-dependent prostate adenocarcinoma cells LNCaP, and slowed down the growth rate. Conclusions: Inhibition of PCDH-PC expression reduced the invasiveness of androgen-independent prostate cancer cells.