Title: Biosynthesis of zinc oxide nanoparticles using Albizia lebbeck stem bark and evaluation of its antimicrobial, antioxidant and antiproliferative activities on human breast cancer cell lines

Biography:

Huzaifa Umar has completed his Masters at the age of 26 years and PhD Studies at the age of 32 from Cyprus International University, Lefkosa, Turkey. He is the assistant director, biotechnology research center, Cyprus International University. He has published more than 15 papers in reputed journals.

Abstract

Biocompatibility and stability of zinc oxide nanoparticles (ZnO NPs) synthesized using plants is a promissing research area of study in nanotechnology, due to its wide applications in biomedical, industrial, cell imaging and biosensor fields. The present study reports the novel green synthesis of stable ZnO NPs using various concentrations of zinc nitrate 0.01, 0.05, 0.1 M, and Albizia lebbeck stem bark extracts as an efficient chelating agent. Antimicrobial, antioxidant, cytotoxic and antiproliferative activities of the synthesized nanoparticles on human breast cancer cell lines, were evaluated using different assays. The UV-vis spectroscopy result revealed an absorption peak in the range of 370 nm. The involvements of A. lebbeck bioactive compounds in the stabilization of the ZnO NPs was confirmed by X-ray diffraction (XRD) and Fourier transform infrared (FTIR) analysis. Zeta sizer studies showed an average size of 66.25 nm with poly disparity index of 0.262. Scanning electron microscope (SEM), Energy-dispersive X-ray spectroscopy (EDX) analysis results, revealed irregular spherical morphology and presence of primarily Zn, C, O, Na, P and K respectively.