Cardiovascular disease (CVD) is the most common cause of death in industrialized countries and blood hypertension is the most frequent treatable risk factor for the development of cardiovascular diseases (CVD). In fact, hypertension is closely associated with a major incidence of stroke (ischaemic and hemorrhagic), myocardial infarction, heart failure, chronic kidney disease, peripheral vascular disease, cognitive decline, and premature death. Emerging data suggest that lifestyle habits may affect blood pressure values. In this review, the authors examine the more relevant clinical and epidemiological studies about the influence that multiple lifestyle factors play on the development of hypertension. They conclude that there is clear evidence that lifestyle changes can have a favorable effect on the prevention and treatment of hypertension, with emphasis on alcohol and sodium intake, smoking cessation, physical activity level, and dietary patterns. Physicians and Public Health Authorities should encourage positive lifestyle modifications. Keywords: Lifestyle, Hypertension, Salt intake, Physical activity, Dietary pattern.