Edmund Kunji holds a PhD in Mathematics and Natural Sciences from the University of Groningen and he has been an EMBO Postdoctoral Fellow with Richard Henderson at the MRC Laboratory of Molecular Biology, Cambridge. Since 2000 he is a Research Group Leader at the MRC Mitochondrial Biology Unit, University of Cambridge, where he works with his group on structures of transport proteins to elucidate the transport processes in mitochondria.
Abstract
Mitochondrial ADP/ATP carriers in the inner membrane belong to the mitochondrial carrier family and they transport ADP into the mitochondrial matrix for ATP synthesis, and ATP out to the cytosol to fuel the cell. They cycle between cytoplasmic-open and matrix-open states, in which the substrate-binding site is alternately accessible from either compartment for ADP or ATP binding.
