Dr Maherunnessa has completed FCPS from Bangladesh College of Physicians & Surgeons (BCPS) in 2003. She is currently employed as an Associate Professor of Gynaecology & Obstetrics at BIRDEM, Dhaka. She has published 14 papers in different journals.
Abstract
A total 110 cases of missed abortion up to 13 weeks were included in this study. Each woman received a single oral dose of tab mifepristone 200 mg and 48 hours later Tab misoprostol 400 µgm was used vaginally 3hourly 3times for termination of pregnancy. Maximum 1200 µgm Tab misoprostol were used. Women who failed to pass the products of conception were offered repeat medical regime with Tab misoprostol. Success was defined as complete uterine evacuation within 3 days, without the need for surgical evacuation. In this study the overall success rate of medical management was 84.54% (93 out of 110). Mifepristone alone induced natural expulsion of products conception was 18 %( 20 out of 110) of women .The median dose of misoprostol was 1200 µgm and the median induction miscarriage interval after prostaglandin administration was 8.04 hours (range: 0.58- 50.54 h).Of the 17 women who had surgical evacuation, 4 required an emergency curettage for bleeding. In conclusion, the combination oral mifepristone 200 mg with vaginal application of misoprostol is an alternative to surgical management of early fetal demise, although it is not as effective as surgery. So it may reduce the need for surgical intervention
