Title: A Genomic Study of Type 2 Diabetics Attending the Outpatient Clinics of Egyptian National Institute of Diabetes and Endocrinology

Biography:

Prof. Dr. Mohsen Khalid has graduated from faculty of medicine Cairo University in November 1980. He has completed his Master degree in Internal Medicine May 1986, and then he completed his Medical Doctorate in Internal Medicine November 2003. He is a consultant of Diabetes and Endocrinology in the Egyptian National Institute of Diabetes and Endocrinology. He has published more than 20 papers in reputed journals.    The research interest of Prof. Dr. Mohsen Khalid is Genetics of Diabetes, diabetic complications and how to assist diabetic patients to live a good life with life style modification and medical treatment.

Abstract

In complex diseases like type 2 diabetes, obesity and cardiovascular diseases, multiple genetic and environmental factors as well as the interaction between these factors determine the phenotype. Although environmental influences, such as high-caloric fat- and carbohydrate-enriched diets and a sedentary lifestyle with markedly reduced physical activity, certainly accelerate disease development in those with genetic predisposition, it is of great clinical importance to explain the genetic variants that increase the risk of diseases like type 2 diabetes.

 A panel of established variant single nucleotide polymorphism ( SNPs ) in patients diagnosed with type 2 diabetes mellitus has been evaluated in many studies compared to a non- diabetic control population .These results were used as a basis of comparison to analyze risk-conferring genotypes in type 2 diabetes mellitus to demonstrate type 2 diabetes risk associated factors . The results of this study provides a better understanding of the genetic epidemiology of type 2 diabetes in Egypt. Identifying genetic markers of type 2 diabetes will help to reduce disease onset and may ultimately adjust future risk factors through the early detection and healthy life style modification.

Our study made an attempt to study the most common single nucleotide polymorphism ( SNPs ) genotypes associated with type 2 diabetic patients attending the outpatient clinic of Egyptian National Institute of Diabetes and Endocrinology.  There was a significant increase in serum levels of FBS, HA1c, TG and LDL in patients group compared to normal healthy controls (P-value < 0.05).While there was no significant difference between patients group and normal healthy controls regarding bilirubin, ALT, AST, creatinine and potassium (P-value > 0.05).