Title: Evaluation of serum high mobility group box1 level in patients with Alopecia Areata

Biography:

Mohamed E. Algalaly is a Major Dermatologist at the Department Of Dermatology in the Armed Forces Medical Complex Kobry El koba, Egypt. He has completed his MSc from Ain Shams University, Egypt. He is member of the Egyptian Military Medical Academy. Recently he works at the German Armed Forces Hospital, Berlin, as a member of an international cooperation training program.

Abstract

Alopecia areata (AA) is the most frequent cause of inflammation-induced hair loss. It is an organ–specific autoimmune disease where T cells and cytokines play an important role in the pathogenesis. High mobility group box1 (HMGB1) is a conserved protein located in all mammalian nuclei at high concentrations. It can be released extracellularly and acts as a proinflammatory cytokine in both acute and chronic inflammatory conditions and serves as a significant target antigen in many autoimmune disorders. However, its role in alopecia areata is under investigation.