Title: Implementing modern cell engineering and process development approaches for affordable and sustainable biosimilar manufacturing

Biography:

Sanjeev Gupta has obtained Ph.D. in Molecular Biology/Cell Line Engineering and M.Sc. in Applied Microbiology and Biotechnology. At present working as Sr. General Manager and Head, Advanced Biotech Lab (R&D-Biosimilar), Ipca Laboratories Ltd., Mumbai, India. Sanjeev Gupta has established a new world class state of the art Biotech R&D facility for the development of mAb Biosimilars. He is also actively involved in establishing modern and lean single use Bio-manufacturing facility for Biosimilar commercial launch.

Abstract

Implementation of gene editing tools CRISPR and TALENS for cell line engineering  and  production improvement. Modern approaches for high producer cell line and robust upstream process development. Use of cutting edge technologies to improve biosimilar development and manufacturing . Factors influences protein expression and critical quality attributes including glycosylation of monoclonal antibodies mAb glycosylation and its overall Impact on biosimilarity and product performance. Case studies on titer and quality improvement at clone and process level for affordable biosimilar development.