Title: Cellular pathology of Alzheimer's disease

Biography:

Mojtaba Mafi graduated from Tehran University, School of Medicine with honor. He studied in neurosurgery ward and graduated with a score with thesis on Meningioma Brain Tumor during 6 years. With continuing his practice with special consideration on psychosomatic disorders, He completed many post graduate courses on health psychology, addiction medicine, sexual disorders therapy successfully and He passed many post graduate courses in Neuro, approved by Medical sciences university and He have been passed post graduate courses on Nutrition, Gastroenterology and hepatology, Obesity treatment and diabetes approved by Tehran University of Medical sciences.

Abstract

Macroscopic Brain appearance in Alzheimer's disease is cortex atrophy with Sulcuses widening is more prominent in frontal, temporal and parietal lobes. Secondary to severe atrophy, we can see ventricles compensatory widening. Extracellular: Neurotic plaques. Intracellular: Neurofibrillary tortuosity, filaments Neurotic plaques: focal and spherical accumulation of dilated neural branches with amyloidosis center. This amyloid center is consisting of B amyloid. In surrounding of these plaques, we find microglial cells and reactive astrocytes. Neurofibrillary filaments: Coupled tortuosed filaments in neurons cytoplasm was seen as basophilic structures. These filaments push cell nucleus protein phosphorylation was seen also.