Title: Some patterns of binary and ternary combined toxicity of metal oxide nanoparticles and its attenuation with bioprotective complexes

Biography:

Ilzira A. Minigalieva is a post graduate fromYekaterinburg Medical Research Centre Prevention and Occupational Health of Industrial Workers, and present working in the department of Toxicology and Biological Prophylaxis.

Abstract

Amplification of Polymorphic DNA (RAPD) test for DNA fragmentation. The same features were assessed in control rats infected intraperitoneally with water with or without administration of the BPC. The copper oxide nanoparticles proved adversely bio-active in all respects considered in this study, their active in vivo solubilisation in biological fluids playing presumably an important role in both toxicokinetics and toxicodynamics. The BPC proposed and tested by us attenuated systemic and target organs toxicity, as well as genotoxicity of this substance. Judging by experimental data obtained in this investigation, occupational exposures to nano-scale copper oxide particles can present a significant health risk while the further search for its management with the help of innocuous bioprotectors seems to be justified.