Biosensors are nowadays omnipresent in medical analysis along with their present in other areas like daily healthcare monitoring, food safety and control, drug delivery systems, wound healing, human physiological signal monitoring and ongoing medical research [1-2]. The global pandemic COVID-19 and it’s worldwide social and human life destruction has shown us, how remote heath care monitoring, digitally health management, physiological signal monitoring etc. are the burning needs of the hour. For the accuracy and comfort of the patient for disease diagnosis, monitoring and treatment, it’s very essential to have a flexible, sensitive, robust, conformable, portable and bio-compatible platform to design the flexible hybrid electronics for bio sensing. It’s also important to rethink and design the rapidly emerging printed and flexible E-skin electronics on a sustainable novel material as well as circular platform that will minimize E-waste and GSG emissions at the very beginning stage of innovation