Title: Skin-like biosensor system via electrochemical channels for noninvasive blood glucose monitoring

Biography:

Yihao Chen has completed his PhD from Tsinghua University and is now a postdoc from the Center for Flexible Electronics Technology, Tsinghua University. He is also the head of the flexible biosensing lab of Global Research Center for flexible electronics & intelligent technology, Hangzhou. He has published more than 10 SCI papers in reputed journals. 4 patents have been granted.

Abstract

Currently, noninvasive glucose monitoring is not widely appreciated because of its uncertain measurement accuracy, weak blood glucose correlation, and inability to detect hyperglycemia/hypoglycemia during sleep. We present a strategy to design and fabricate a skin-like biosensor system for noninvasive, in situ, and highly accurate intravascular blood glucose monitoring. The system integrates an ultrathin skin-like biosensor with paper battery–powered electrochemical twin channels (ETCs). The designed subcutaneous ETCs drive intravascular blood glucose out of the vessel and transport it to the skin surface. The ultrathin (~3 mm) nanostructured biosensor, with high sensitivity (130.4 mA/mM), fully absorbs and measures the glucose, owing to its extreme conformability. We conducted in vivo human clinical trials. The noninvasive measurement results for intravascular blood glucose showed a high correlation (>0.9) with clinically measured blood glucose levels. The system opens up new prospects for clinical-grade noninvasive continuous glucose monitoring.