Title: Development of electrochemical aptasensor for diagnostics and monitoring of multiple sclerosis

Biography:

P. Kara  has completed his PhD at the age of 28 years from Ege University and Postdoctoral Studies from Faculty of Pharmacy, Ege University, Turkey. She is the group leader of Bioelectronics & Biosensing group in Analytical Chemistry Department, in same uniersity. She has published more than 40 papers in reputed journals.

Abstract

Neurodegenerative diseases are associated with progressive and irreversible loss of neurons in specific areas of the central nervous system (CNS). Multiple sclerosis (MS) is a recurrent and progressive inflammatory, demyelinating disease of the CNS. Nowadays, the number of MS patients is increasing, but the diagnostic process is still quite difficult and costly and requires combination of various methods and analysis. Myelin is a structure made up of a few proteins located between two lipid layers tightly wrapping the axons of neuro cells, which is necessary for rapid providing of electrical signal between CNS and body. Myelin basic protein (MBP) makes up to 30% of myelin and it is known to be released into the cerebrospinal fluid (CSF) as a bioindicator of MS ¹. In addition, in case of another demyelinating disease or trauma of CNS, MBP is present as a biomarker in human blood serum