Title: Development of tizanidine HCl-Meloxicam loaded polymeric mucoadhesive buccal films: In-vitro and in-vivo evaluation

Biography:

PhD Scholar, doing PhD in Pharmaceutics and working on the project of extraction and modification of natural polymers and their use in development of drug delivery system.  I have expertise in development and evaluation of different types of dosage forms including tablets (orodispersable, sustained release matrix tablets, gastro retentive drug delivery, mucoadhesive tablets), capsules, gels, microspheres, microsponges, nanoparticles, transdermal patches and buccal films (immediate release and sustained release mucoadhesive buccal films). Moreover, has expertise in extraction and modification of polymers and their use as the carriers for delivery of various drugs. Also has expertise in development and validation of HPLC methods for identification and quantification of drugs alone as well as for simultaneous determination.

Abstract

The purpose of the study was to develop Tizanidine HCl (TZN) and Meloxicam (MLX) loaded bilayer mucoadhesive films intended for buccal administration, aiming to enhance the bioavailability. Bilayer films were prepared by solvent evaporation technique selecting arabinoxylan (ARX) as a sustained release (SR) layer forming polymer and hydroxypropyl methylcellulose (HPMC) E-15 as an immediate release (IR) layer forming polymer. Prepared films were subjected to in-vitro drug release, surface morphology, mechanical strength, compatibility of the ingredients, drug contents, ex-vivo mucoadhesion strength and drug permeation. Crossover study design was applied to study the in-vivo pharmacokinetics by using albino rabbits. Various pharmacokinetic parameters including AUC, Cmax, Tmax and T1/2 of both drugs loaded in films were compared with standard solution/dispersion. The results unveiled instant release and permeation of MLX from IR layer, while good controlled release and permeation characteristics of TZN from SR films over 8 h. films were of uniform thickness with smooth surface and satisfactory mechanical strength. Mucoadhesion strength was sufficient to provide suitable contact time with mucosal membrane. The pharmacokinetic study exhibited prompt absorption of MLX with better AUC 0-t (6655.64 vs 6538.99) and Cmax (436.98 vs 411.33) from oral dispersion. Similarly buccal films has shown enhanced half-life (9.91hr vs 2.51 hr), AUC 0-t (1043.4 vs 149.1) and Cmax (91.92 ng/ml vs 42.29 ng/ml) from oral solution. A statistical investigation disclosed a significantly improved pharmacokinetics of TZN and MLX after their absorption across buccal route following administration of F-ARX (p<0.05). ARX proved expedient and bilayer buccal films as a drug delivery system ascertained the dual effect of providing instant release of one active agent and persistent release of another one with improved pharmacokinetics