Abstract Background: Lung cancer stem cells play a major role in lung cancer metastasis, drug resistance and tumor-self-renewal. The miRNA profile of CSCs is remarkably different from non-stem cancer cells. As such, many miRNAs have been shown to regulate self-renewal and differentiation properties of CSCs. Also, MicroRNAs play a significant role in shaping immune response. Aim, aim of this study was to analyze the numbers of these cells in non-small cell lung cancer patients (NSCLC) before and after induction of chemotherapy and measure the relative expression of miRNAs. Materials and Methods: The frequencies of CD45- , Epcam+ and CD133+ cells as compared to healthy controls were analyzed in the peripheral blood of NSCLC patients before (n= 10) and after (n= 10) chemotherapy using multiparametric flow cytometry. The gene expression of miRNAs in Peripheral Blood was measured using microarray. Results: early diagnosed patients before induction of chemotherapy showed high numbers of Epcam+ and CD133+ CSCs when compared to CTRL; where the numbers of these cells were decreased after treatment as compared to CTRL and before treatment. A significant upregulation of miRNAs and downregulation of miRNAs were observed in the PBMCs of NSCLC patients as compared to healthy controls. Conclusion: current study opens a new avenue to investigate the mechanism mediating the emergence of these cells on larger number of NSCLC patients at before and after treatment stages. Also, identified potential key molecules and provides a basis for investigations of tumor development as well as novel drug targets for non-small lung cancer treatment

As the world considers reopening schools after the COVID-19 pandemic, policymakers and administrators need to consider how to reopen in a way that keeps students and staff safe. This brief provides insight into health and safety guidelines and social distancing strategies used in other countries that have successfully reopened their schools in the context of COVID-19. Examples are intended to support school policymakers and administrators in the United Arab Emirates as they are reopening. Introduction: Schools across the globe canceled in-person classes beginning in March 2020 to contain the spread of the COVID-19 virus. In many countries, school buildings are closed for the duration of the school year. Across the globe, policymakers and school leaders started making plans to reopen schools for the 2021-22 academic year. In order to reopen schools safely and mitigate disease spread, state and WHO and global leaders started to address several important health considerations that are specifically pertaining to schools and learning institutions.

Topics:

• Attendance and Health Screening
• Attendance Policy
• Health Screening and Quarantine Procedures
• School Closure
• Social Distancing
• Hygiene and Cleaning