Ischemic nephropaty (IN)is associated with an increased risk for progressive decline in renal function especially when present from a long time. The most common cause of IN  is related to renal artery stenosis (RAS) and this is in a mayor of case do to atherosclerotic lesions, and with minor impact by fibromuscular dysplasia. Percutaneous transluminal renal angioplasty (PTRA) with or without stenting is one of the standard treatments for severe RAS. It’s also estabilshed    the correct timing of revascularization before hypoxia led to irreversible kidney damage. Randomized controlled trials comparing medical therapy with PTRA to medical therapy alone have failed to show a benefit of PTRA; however diferent studies have valuated the effects of PTRA treatment only on  blood pressure and renal function and never studied wich factors were could be able to repairs the organ demage. As demostratde that   in the adult human kidney, CD133, CD24  cells are a  progenitors that are arranged in a precise sequence within Bowman’s capsule and exhibit heterogeneous potential for differentiation and regeneration. Using the dosage of renal staminal cells  we identifies and confim factors (clinicale and strumentals) that may predict which patients are most likely to benefit from PTRA.

Chronic Kidney Disease [ CKD ] afflicts approximately 7-10% of Adult Population. The manifestations of CKD are varied and can mimic a variety of medical and surgical conditions.  It is a silent killer due to its far reaching ill effects on the cardiovascular system. Early recognition is of paramount importance since preventive strategies are successful only if applied before irreversible renal fibrosis sets in. This talk will provide an  overview of Paradigm shift in our focus on various risk factors.

 The old fashioned recommendation of  blanket dietary Protein restriction now applies more  to meat based diets and not for vegetable proteins. Multiple lines of evidences are in favour of  Plant Based dietary   Protein intake  with reno protective benefits  due to their  alkaline nature and fibre content. In addition, Plant Based Protein intrake results in reduced Phosphate absorption which is advantageous in curtailing release of FGF-23 and PTH.