Introduction: Obesity may cause progressive chronic kidney disease. Weight loss in the postoperative follow-up of bariatric surgery may improve renal function in these patients. Thus, the purpose of this study was to give insight on the subject using a sensible biomarker.

Methods: This cross sectional study was performed in the Obesity Department from Campina Grande – Paraiba, Brazil. It was randomly enrolled 23 postoperative patients (7 bypass and 16 sleeve), with at least two years of follow-up, from the outpatient Department and 29 (18 bypass and 11 sleeve) in the preoperative period for bariatric surgery. They were homogeneously from both genders with ages ranging from 25 to 57 years. Serum levels of creatinine and cystatin C were measured, and the glomerular filtration rate (GFR) was estimated using the CKD Epi (chronic kidney disease epidemiology collaboration) cystatin-creatinine equation. The investigation was approved by the Ethics Committee.

Results: The mean body mass index (BMI) of the preoperative group was significantly greater than the postoperative group (p ≤ 0.0001). The mean serum levels of C cystatin was significantly greater in the postoperative group as compared to preoperative (p= 0.0197). However, there was no mean difference between creatinine serum concentrations comparing the two groups (p = 0.3252). The mean glomerular renal function rates of the groups were similar (p = 0.1240).

Conclusion: There is no definitive evidence for supporting the hypothesis that there is improvement in the kidney renal function after bariatric surgery in obese patients. Prospective cohorts are necessary to enlighten the answer for this important question.

Ischemic nephropaty (IN)is associated with an increased risk for progressive decline in renal function especially when present from a long time. The most common cause of IN  is related to renal artery stenosis (RAS) and this is in a mayor of case do to atherosclerotic lesions, and with minor impact by fibromuscular dysplasia. Percutaneous transluminal renal angioplasty (PTRA) with or without stenting is one of the standard treatments for severe RAS. It’s also estabilshed    the correct timing of revascularization before hypoxia led to irreversible kidney damage. Randomized controlled trials comparing medical therapy with PTRA to medical therapy alone have failed to show a benefit of PTRA; however diferent studies have valuated the effects of PTRA treatment only on  blood pressure and renal function and never studied wich factors were could be able to repairs the organ demage. As demostratde that   in the adult human kidney, CD133, CD24  cells are a  progenitors that are arranged in a precise sequence within Bowman’s capsule and exhibit heterogeneous potential for differentiation and regeneration. Using the dosage of renal staminal cells  we identifies and confim factors (clinicale and strumentals) that may predict which patients are most likely to benefit from PTRA.