Title: Split foot sign in Amyotrophic lateral sclerosis (ALS)

Biography:

 The muscle patterns involved in amyotrophic lateral sclerosis (ALS) remains controversial. split leg and split hand signs were assessed previously. However; foot muscles involvement could be not equal in ALS like in case of split hand sign with preference for lateral hand muscles.

Abstract

We recruited 11 patients with ALS and 12 healthy controls. Compound Muscle Action Potentials (CMAPs) were recorded over the EDB, ADM and AH muscles in all subjects. EDB/AH and ADM/AH ratios were obtained and compared between patients and controls.

The EDB/AH and ADM/AH CMAP amplitude ratio were significantly reduced in patients with ALS (0.26 +_ 0.16, P = 0.001) and (0.27 +_ 0.10, p = 0.001) respectively. These findings indicate a greater loss of lower motor neurons innervating the EDB and ADM and dysfunction of spinal motor neurons innervating these muscles. The EDB/AH and ADM/AH CMAP ratios reliably differentiated patients from HCs, with AUCs of 0.42 (95% CI 0.00-0.9) and 0.41 (95% CI 0.00–0.95), sensitivities of 78%, and specificities of 100% for both with cut-off ratios of 0.12 and 0.15 recpectively