Gene therapy is an experimental technique that uses genes to treat or prevent disease. In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient’s cells instead of using drugs or surgery. Researchers are testing several approaches to gene therapy, although gene therapy is a promising treatment option for a number of diseases (including inherited disorders, some types of cancer, and certain viral infections), the technique remains risky and is still under study to make sure that it will be safe and effective. Gene therapy is currently being tested only for diseases that have no other cures. In the Coming Presentation I will Talk about the given below topic.

The present study investigated the fermentation pattern and morphological characteristics of rumen in goats fed high concentrate diet with or without selenium supplementation. A total of fifteen young goats were divided into three dietary groups, viz. LC, HC and HCS with 5 animals in each group either fed low concentrate (LC, roughage: concentrate ratio 65:35), high
concentrate (HC, 35:65) or HC plus Se (HCS) diets. Se was supplemented as selenium yeast at the dose rate of 0.3 mg Se/kg of diet. The experiment lasted for 10 weeks. Ruminal fluid and tissue samples were collected for analysis of fermentation pattern and histomorphometry. The fermentation pattern showed an increase in molar concentrations of acetate, propionate and butyrate in both HC and HCS groups compared to LC except for acetate that significantly decreased (P < 0.05) in HCS compared to HC. The drop in ruminal fluid pH was highly significant (P < 0.005) in HC fed than that of HCS fed (P < 0.05) goats compared to LC. Histomorphometric analysis showed severe damage concurrent with significant decrease in antioxidant enzymes in rumen epithelium of HC-fed goats compared to control, however, the selenium supplementation in HCS goats ameliorated the damaging effects of HC diet. The results of present study suggests that HC diet alters fermentation pattern and induces epithelial damage by increasing oxidative stress and the selenium supplementation ameliorates HC diet-induced epithelial damage in rumen of goat.

Key words: Selenium yeast, rumen epithelium, oxidative stress, epithelial damage, goat.