Taherah Mohammadabadi is a Professor, Faculty of Animal Science and Food Technology, Agricultural Sciences and Natural Resources University of Khuzestan, Iran
There are various anti-diabetic drugs to treat diabetes but they have several negative effects on the patients’ health. Although the proper treatment of diabetes includes insulin injection continuously to maintain blood glucose level, but nowadays, the researchers following some natural alternative healings for insulin. Camel milk contains insulin like proteins, which does not form coagulum in the acidic condition of stomach, can be absorbed from the intestine and may be an effective alternative for insulin to treat type 1 and 2 and gestational diabetes. Camel milk is believed to be a suitable hypoglycemic agent in improving long-term glycemic control in experimental animals and patients with diabetes. The incidence risk of diabetes in people who regularly consume camel milk, is much lower than those who don’t use camel milk. Camel milk may prepare about 60% of the insulin in diabetic patients and reduce blood sugar and required insulin dose about 30–35% in type 1 diabetes patients. Raw camel milk has immune- modulatory effects on beta-cells of the pancreas, increase insulin secretion, reduces required insulin and insulin resistance and improves the glycemic control in type 1 diabetes patients. Camel milk improves the diabetes complications such as obesity, inflammation, wounds and oxidative stress damages. Lactoferrin of camel milk has immune- modulatory effects on pancreas beta-cells and reduces required insulin doses in diabetes 1 and 2 patients. Obviously, camel milk effects on regulating of blood glucose are including; effect on insulin receptor function, signaling and glucose transport in the insulin-sensitive tissues, effect on the growth and activity of the pancreatic beta-cells in insulin secretion and negative modulation on the glucagon receptor. In most of the clinical trials, the favorable effects of raw camel milk on diabetes mellitus observed by the recommended dose 500 mL/day for 3 months which also improve risk factors in diabetic patients. It appears that more scientific studies are needed to confirm the effectiveness of processed and camel milk powder on diabetes cases.
Aya Sobhy is passionate about science specifically immunology and the future possibilities it could offer. She has a unique experience in research and scientific writing as she publisher her 2 graduation projects and this project is one of them also has been a former researcher at 57357, National center of oncology and immunology department Cairo university nevertheless, she has a great talent of multi-tasking as for now she is a Master student in immunology, science communicator, tutor for Biology & chemistry for American diploma students, scientific editor and researcher assistant.
Cryptosporidiosis has been considered as a serious diarrheal disease, especially in immunodeficient patients, where they failed to clear the infection leading to several consequences of infection (i.e death). The role of cell mediated immunity in clearing the infection was demonstrated by the increased susceptibility of HIV/AIDS patients to infection. To date, no specific treatment has been proven for cryptosporidiosis in immunodeficient patients. The study aimed to evaluate the efficacy of Aloe vera gel for the treatment of cryptosporidiosis in immunocompetent and dexamethasone immunosuppressed mice in comparison to that of nitazoxanide. Mice were orally administrated with Aloe vera gel, in a daily dose of 250 mg/L in drinking water, for 14 consecutive days post infection. Parasitological, molecular and immunological measurements were recorded on the 7th, 14th, 21st and 32nd days post infection. Our in vitro results showed that 250 mg/L of prepared gel achieved the highest parasitic reduction. The body weights of Aloe vera treated mice on the 21st and 32nd day post infection, either in immunocompetent or immunosuppressed groups, were nearly the same as those of their corresponding control groups. Aloe vera gel succeeded in clearing cryptosporidiosis with a percent reduction of 100% in immuno- competent mice and 99.67% in immunosuppressed mice. The anti-inflammatory effect of Aloe vera reduced the levels of IFN-γ, IL-4, -6 and -17. The success of Aloe vera gel, in clearing cryptosporidiosis in immunosuppressed mice, was obvious either from the reduction of Cryptosporidium DNA or the oocysts in stool samples; and from the improvement of histopathological sections.