Webinar on
Clinical Pediatrics
May 29, 2021
Scientific Program
Keynote Session:
Title: New therapeutic and diagnostic for rheumatoid arthritis, and autoimmune disease using novel biomimetics
Biography:
Kira Astakhova is an associate professor at the Department of Chemistry, Technical University of Denmark. She received multiple awards and honour fellowships including Jorck research award, Lundbeck research fellow, Marie Curie Early Stage Training and Carlsberg Foundation Elite Award. She is a co-author of 50 scientific articles and 5 approved patents and patent applications. Current research by her and her group is focused on the synthesis and studies of advanced biomolecular analogues and nanomaterials. This includes development of new design, synthetic strategies and assays which take advantage of the functionalized nucleic acids, peptides, proteins and lipids. In doing this we actively integrate methods of computational chemistry, organic synthesis and biomedicine.
Abstract:
This project aims for the personalized management of Rheumatoid Arthritis (RA) with a novel therapeutic supported by an effective diagnostic approach. Our goal is to fulfil unmet needs in managing the disease as currently there is no proposed solution. Our mission is to improve healthcare in society using the most recent developments in chemistry, synthetic biology and medicine. RA is a condition when the immune system loses specificity, and instead of destroying intruders of the body it attacks the body’s own cells. As much as 1% of the world population is affected by RA which leads to pain and physical disability for most patients. Despite over four decades of research, neither specific diagnostic nor effective treatment is available. We propose a new therapeutic linked with an earlier diagnostic technique. The new technology applies rationally designed synthetic antigens and their nanoparticles for the specific diagnostics and treatment of RA. The technology has a potential to dramatically improve the life quality of RA patients while reducing the disease management costs in the healthcare system. We believe that this mission will be accompanied by building a high revenue business that will take a market share estimated in billions of USD. The therapy will specifically bind and clear the inflammatory autoantibodies and cells that cause the disease. At the molecular level, it provides the treatment of inflammation causing autoantibodies and prevents their cytotoxic activity. At the cellular level, the RA associated osteoclasts are specifically targeted. The diagnostic method offers an earlier diagnostic which means less permanent disability for the patient. The diagnostic development is complete, and it is already benchmarked. The team is composed of a PI Kira Astakhova (chemistry, biomedicine), Postdoc Dr. Tiago Silva (pharmacy), Researcher Sangita Khatri (chemistry), and a project manager Lisa-Marie Jaunet (business development).
Title: Risk factors predicting insulin resistance in obese adolescents
Biography:
Ramy Mohammed M El-Sherbini has received MBBCh from faculty of medicine Cairo University, MSc in pediatrics from faculty of medicine Cairo University-Abou El-Rish hospital and PhD from institute of postgraduate childhood studies. He is a researcher of biological anthropology, consultant of pediatrics and neonatology at National research center Dokki. He has published six international publications and presented as national and international speaker, attended two international conferences in Yokahama (Japan) and Prague (Chezch Republic) and attended noble prize dialogue in Japan. He attended 10th hope meeting in Yokahama in Japan and presented two intentional poster presentations in Yokahama and Egypt. He is a member of the Egyptian Society of Neonatology, the Arab Society of Medical Research and Japanese society for promotion of science (JSPS). He worked as a pediatric consultant in many hospitals, worked as an organizer of Ganna hospital. He was awarded as the best speaker in 14th annual conference (diabetes, gut and the liver) by the Egyptian association for the study of liver and gasterointestinal disease (EASLGD).
Abstract:
Obesity is a hazard mark associated with insulin resistance (IR). This study aimed to detect which risk factors might provide the greatest predictive value for IR in obese adolescents aged thirteen to seventeen years. One hundred obese adolescents with IR and matched age and sex 100 obese healthy controls without IR were included. Anthropometry, serum lipids and metabolic biomarkers were measured. Homeostasis model assessment of insulin resistance (HOMA-IR) was used to determine insulin resistance. Significant increase in serum lipids and metabolic parameters in obese cases with IR compared to those without. Positive correlations were observed between obesity measurements and metabolic risk markers, including increase of waist to hip ratio (WHR), sum of skin folds, blood pressure, insulin, HOMA-IR, TC, TG and LDL-C levels and decrease of HDL-C in IR adolescents. WHR showed the highest correlations with biochemical markers in IR cases. WHR was able to predict IR with area under the curve = 0.82 and TG-to-HDL-C ratio with area under the curve = 0.87. WHR and lipid/lipoprotein fractions are significantly associated with IR in obese adolescents and might be used for the prediction of IR and for cases at high risk for early intervention.
Title: Is health care a right or a privilege in the United States?
Biography:
Carol Apt received her PhD in Sociology, with a concentration in medical sociology, from Northeastern University in Boston, Massachusetts, and is a professor of sociology at South Carolina State University in Orangeburg, South Carolina, USA, where she has been for the last 20 years. She teaches courses in human sexuality, medical sociology, social problems, and the sociology of genocide, a course she developed for the University. In 2011 she was honoured as the South Carolina State University Professor of the Year. As a medical sociologist, she is a consulting member of the South Carolina Medical Association Bioethics Committee. In addition to her background as an author and a newspaper and magazine columnist, she is the host of a radio talk show entitled, “Talk to Me,†which addresses issues of sexuality and relationships.
Abstract:
A right is something that is guaranteed and protected by a higher authority, such as a government, whereas a privilege is a special advantage or benefit that is granted to a person, a group, or to a category of people. A privilege, therefore, is granted to some and denied to others. The right to health care, or as some would say, the right to health, is a basic human right, as codified by international human rights law by the World Health Organization (1946), the Universal Declaration of Human Rights (1948), and the World Conference on Human Rights (1993). This presentation will compare the opinions of experts in the field of health care as to whether it is a right or a privilege in the United States. Most Americans access health care through their employers; for those people health care is a right. However, since 2005 most new jobs added to the economy have been classified as part-time, temporary, or seasons, which mean that they don’t provide access to health care for employees. While the majority of Americans claim to be in favour of universal health care, the United States doesn’t have it; 44 million Americans have no health insurance and 38 million Americans are underinsured. This presentation will examine some of the arguments surrounding the controversial subject of universal health care in an attempt to understand why we don’t have it. The history of connecting access to health care through employment will also be discussed.
Title: Synchronization of pupil dilations reveals team performance
Biography:
Wenjing He has completed PhD in surgical simulation specializing in team training and team performance assessment using eye tracking and motion tracking evidences at University of Alberta. She has four years simulation instruction experience in team training and team work assessment. She also has the experience in simulation design, training and evaluation. Currently she is the manager of Surgical Simulation Research Lab (SSRL).
Abstract:
