Nowadays ultrasound wound and skin treatment including infection control has been gaining interest in hospitals, clinics, wound care centers and doctors’ offices. The purpose of this presentation is to share, review, and evaluate the safety, validity, and efficacy of ultrasound treatment of all types of acute and chronic wounds including diabetic foot ulcers and share the results with the existing and future users by enhancing their understanding of potential positive outcomes from using the different ultrasound devices in wound management. For wound treatment purposes the low and high frequency ultrasound devices have been used, which have been in clinical trials or marketed worldwide. The ultrasonic parameters and design of instruments are very influential and critical for different aspects of wound treatment, such as ultrasonic energy delivery to target, tissue fractionation/ fragmentation/ debridement, liquefaction/ histotripsy, erosion, homogenization, liquation and wound therapy. Ultrasound treatment applies effective ways to prevent damage to surrounding healthy tissue and to succeed in therapeutic wound treatment. Treatment was both contact and non-contact modes, depending on the manufacturers, high and low frequency devices and wound conditions such as acute, infected, chronic, trauma, diabetic, non-diabetic, burn, radiation related, animal bite, gun shut, hard-to-heal, etc. The Qoustic Wound Therapy System® medical device is Arobella’s flagship wound care product sold in domestic and international markets. The system is cutting edge wound care offering previously unseen benefits to patients.  This is evident from competitors’ unsuccessful efforts to catch up with Arobella’s technical advances by releasing similar devices. Devices advantages: less pain or no pain, selective debridement, preparation of wound bed for skin grafting, excisional debridement, contact and non-contact ultrasound therapy, increase of SPP, strong bactericidal effect, less scars, etc.