Title: Nobel and advances treatments neurodegerative diseases

Biography:

Domingo Guerra studied at the medical school from Pontificia Universidad Catolica Madre y Maestra, Dominican Republic. While performing as an outstanding student he was a physiology tutor and professor’s assistant, graduated with honors. He was then admitted to the general surgery residency, where he performed as Chief Resident during his final year, and where he also graduated with highest honors. While having a tremendous career as a surgeon, as science advanced into more deep grounds, he decided to start looking into and studying regenerative medicine, cellular culturing, peptide therapy. As of 2002, he started his regenerative medicine practice (along with his surgical practice) becoming a pioneer in the field in the Dominican Republic. Now after 20 years of a successful career, more than approximately 1,600 patients treated, he has received numerous awards, IOCIM (International Organization for medical research and capacitation) Medical Research Award, Professional Health Excellency, and Prize to the Medical by Achievement for a Better Life. Speaker in various conferences, and numerous interviews, he is now fully dedicated to his Regenerative Medicine practice and research, with outstanding clinical outcomes in patients with degenerative diseases and continuing to update his practice as science advances with new discoveries

Abstract

Our study consists in a series of clinical cases. It includes neurodegenerative diseases such as Alzheimer’s, Parkinson’s; stroke, small vessels diseases and cervical trauma; among other.
Symptoms of neuronal damage were present in all of the patients, these included: memory loss, cognitive impairment, hearing impairment (some cases with complete hearing loss), visual impairments (and loss), loss of balance, fine motor skills decline, loss of sphincter control, gait impairment, tremor, and muscular rigidity. All of which translated to incapacity in performing basic life activities (eating, getting dressed, doing dishes, bathing). These symptoms have been proven to ameliorate (and in some instances disappear) through the use of stem cells and regenerative therapy, increasing function and prolonging life expectancy with better life quality.
In this study neurotrophins along with BDNF were given directive or with signalling substances, such as:
• IGF 1 (and analogs)
• P21 gene stimulator: which targets the entirety of the nervous system (both peripheral and
central)
• Selank and Semax: peptides that improve the cerebral vascular system and stimulate the
production of neurons and reduce stress/inflammation in the glial system
• Growth Hormone: influences neuronal development while reducing inflammation
. Different cytokines for improve immunologic system; reduce inflammation and fibrosis.
• Epithelia: a peptide that improves the hypothalamus-pituitary axis improving both nervous and
endocrine system
Signalling and activation of diverse types of Stem cells for diverse chronic diseases is becoming today the treatment gold standard in regenerative medicine. This is being used alongside with genetic activation of specific genes that have been silenced due to oxidative stress, mutations, external factors, and etcetera.
It is to be noticed that certain carrier proteins and their affinity for both nuclear and mitochondrial receptors have an important role as well in regenerative medicine. Focus is being targeted to the glutamate (especially NMDA), glycine, serotoninergic, dopaminergic; gabaergic and cholinergic receptors when it comes to the treatment of neurodegenerative diseases. This is a very promising source of treatment and even cure of certain neurodegenerative conditions; moreover, it is noticeable that these novel therapies also have a positive impact almost of these conditions.

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