International Conference on
Reproductive Medicine & Biology
Scientific Program
Sarwat jahan
PhD, Quaid I azam University, Pakistan
Biography:
Sarwat Jahan has her expertise in reproduction and passion in improving the health. Her open and related assessment model based on heat induced food reproductive toxicants that disturb the reproductive healthcare. She has constructed this study after years of experience in research, evaluation, teaching and administration both in hospital and education institutions. The current finding is based on F1 Extended one generation reproductive toxicity. The aim of this lab is to provide opportunity for students to specialize in human reproductive biology considering both basic science and clinical aspects of the subject. She has practical experience in major laboratory techniques including histological studies, hormone assays, bio chemical assays, assessment of sperm and the application of molecular biology to reproductive medicines are part of the studies conducted. The lab has active collaboration with Salma and Kafeel Infertility Clinic, Islamabad, Centre of Excellence for bovine genetics Renala Khurd, Okara under control of Pakistan army and Cleveland clinic in America.
Abstract
Sprague Dawley F0 weaning rats (30/sex/group) were exposed to furan orally at 0, 5,10, 20 and 40 mg/kg/day for ten weeks (males), two weeks (females) and then mated. F0 females were continuously exposed through gestation and lactation of F1 litters. Different parameters in F0 and F1 generation were studied. Results of F0 indicated that the body weight gain decreased during prebreed and gestational period while increased during lactation periods. F0 animals prebreeding exposure resulted in head tilt and foot splay at higher doses. Reproductive indices and gestational length of F0 animals were remained unchanged. Number of live pups at birth were decreased at 20 & 40 mgkg-1. Weaning pups were distributed into study groups by sex. Survival of F l pups was reduced at 20 & 40 mgkg-1 only for PND 0 through PND 4. At PND 70, hormonal concentration and histological changes were determined in ovaries and testis. In males, Testosterone and LH levels were decreased while increase in estrogen level of females was seen in 20 or 40 mgkg-1 groups. Testicular and ovarian weight was reduced in F1 offspring with decreased DSP and disturbed estrous cyclicity in higher doses groups. No histopathological changes were observed in testis and ovaries but in higher doses groups, number of cystic follicles were increased in ovaries. On the basis of above results, it is suggested that furan exposure at 20 or 40 mgkg-1 exhibit marked changes in extended one generation reproductive toxicity study in F0 (parental stage) and F1 (offspring and pubertal stage) animals.
- Reproductive Endocrinology
- Cryopreservation
- Reproductive Physiology and Metabolic Disorders
- Assisted Reproductive Technology (ART)
- Reproductive Medicine & Sexually Transmitted Diseases
- Reproductive Immunology
- Obstetrics & Obstetricians
- Infertility Drugs and related risk
- Fertility Awareness & Human Reproductive Cancers
- Polycystic Ovary Syndrome (PCOS)
- Latest Innovation in Gynaecological Pathology
- Oncology & Its subdivision
- Reproductive Health & Hazards
- Reproductive Toxicology
