International Conference on

Reproductive Medicine & Biology

Scientific Program

Lisa Oliver

Lisa Oliver

University of Nantes, France

Title: Current status of sexuality education in Europe

Biography:

Lisa Oliver has completed her PhD at University of Paris 7. She is currently working in the group of Dr. François Vallette at the CRCINA, INSERM-University of Nantes. She has published more than 40 papers in reputed journals.

Abstract

Glioblastoma multiforme is the most common brain cancer in adults. Radiotherapy is the most effective post-operative treatment for the patients even though gliomas are considered one of the most radio-resistant tumors. As a consequence there is rapid recurrence of the tumor probably due to the presence of cancer stem cells (CSC), which are radio-resistant. Indeed, the dying irradiated tumor bulk would activate caspase-dependent pathways causing the release of growth-promoting factors that would mobilize and recruit CSC. One of these pathways is the Ca2+-dependent phospholipase A2, the activation of which increases the synthesis and release of arachidonic acid from apoptotic cells and the consequent release of prostaglandin E2 (PGE2). We have evaluated the role of PGE2 in glioma radio-resistance. We used an in-vitro approach using 3D primary cultures derived from representative glioma patients. We show that irradiated glioma cells produced and released PGE2 in important quantities independently of the induction of cell death. We demonstrate that the addition of PGE2 enhances cell survival and proliferation though its ability to trans activate the Epithelial Growth Factor receptor (EGFR) and to activate β-catenin. Indeed, PGE2 can substitute for EGF to promote primary cultures survival and growth in vitro and the effect is likely to occur though the prostaglandin E2 receptor EP2.  

  • Reproductive Endocrinology
  • Cryopreservation
  • Reproductive Physiology and Metabolic Disorders
  • Assisted Reproductive Technology (ART)
  • Reproductive Medicine & Sexually Transmitted Diseases
  • Reproductive Immunology
  • Obstetrics & Obstetricians
  • Infertility Drugs and related risk
  • Fertility Awareness & Human Reproductive Cancers
  • Polycystic Ovary Syndrome (PCOS)
  • Latest Innovation in Gynaecological Pathology
  • Oncology & Its subdivision
  • Reproductive Health & Hazards
  • Reproductive Toxicology