Title: Nimbolide abrogates cerulein-induced chronic pancreatitis by modulating Wnt/β-catenin/Smad in a Sirtuin 1-dependent way

Biography:

Sapana Bansod is a PhD student in the Department of Pharmacology and Toxicology at NIPER Hyderabad, India’s Pioneer Pharmaceutical Research Institute. She has Proficient knowledge and expertise in acute and chronic pancreatitis, liver fibrosis, genotoxicity and molecular biology. Her current research includes exploration of novel pharmacological interventions in cerulein-induced pancreatitis. She has first time developed and standardized the short-term chronic pancreatitis model in swiss mice. She is highly motivated, enthusiastic experimental pharmacologist.

Abstract

Chronic pancreatitis (CP) is characterized by pancreatic inflammation and fibrosis, which leads to impairment of pancreas function. The present study was designed to investigate the possible mechanisms of chronic pancreatitis and the anti-inflammatory, antioxidant and anti-fibrotic effect of nimbolide (NB), active constituent of neem tree Azadirachta indica in cerulein-induced CP.