Title: Statins: A Distant Hope, Thousands Dangers in Near

Biography:

Majid Malaki assistant professor Sevome Shaban Hospital Tehran, Iran

Abstract

We hear daily a lot about statins , a commonly used drug for dyslipedemia, effective on cardiovascular diseases risks,while  most  studies that evaluate statins benefits ignore its side effects they analyse selective age groups of lower 65 and over 30 years and extend their results to all .one of them published In 1995 showed that Statins decrease hazard risk of cardiovascular events when taking regularly for 5 years [1] while 21 years after then it was revealed that in age over 60, LDL-C level is not associated with CVD risk but inversely  can attribute to all-cause mortality [2]Statins have well known side effects and many others have not been described completely such as diabetes mellitus and renal dysfunction that may lead to insidious and fatal acute renal failure following rhabdomyolisis especially after some types of statins such as cerivastain [3,4]. Association of statins with cancer in prolonged use is another side effects that is not proved or rejected until now [5] statins safety is an unknown concept because of different physiologic nature of older and younger people [6]. Statins’s forbidden during pregnancy and breast feeding back to different biologic actions of statins because of cholesterol plays important role in growth and development of younger age, cholesterol is a part of steroid hormones that play role in sexual process metabolisms and bile salts structures , these show safety of a drug in adults should not be addressed to children [7].

Conclusion : statins dangers versus benefits should be individualize always.