Title: Mycobacterium Tuberculosis Infection of a Total Ankle Implant Following Bacillus Calmette-Guerin Administration for Treatment of Bladder Carcinoma

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Abstract

Intravesical bacillus Calmette-Guerin (BCG) instillation is a commonly used treatment for urothelial bladder carcinoma. Soft tissue manifestation of Mycobacterium tuberculosis (M. tuberculosis) following administration of BCG is exceedingly rare. Few cases of periprosthetic M. tuberculosis infections have been reported, however they have been isolated to the hip and knee. This case study presents a well-healed total ankle arthroplasty subsequently infected with M. tuberculosis resulting in a non-salvageable limb. It is important to also be cognizant of the treatment algorithm for infected total arthroplasties as there is some debate in the current literature as to when to explant the hardware. Here we will clearly define our treatment procedure to give insight on the future of management of infected arthroplasties