International Conference on

Oral Health and Hygiene

Scientific Program

Francis Mante

Francis Mante

University of Pennsylvania, United States of America

Title: Effect of fluoride treatment on oral cancer irradiated enamel and dentin

Biography:

Francis Mante is a general dentist and dental biomaterials researcher.  The focus of his research is the development of new restorative materials and improvement of currently available ones. He has extensive expertise in materials science with particular interest in dental composites and ceramics. He has several peer reviewed publications and has served as keynote speaker at dental conferences.

Abstract

Radiation related caries (RRC) is a complication of the treatment of oral cancer and nearly 25% of patients develop RRC following head and neck radiotherapy. Recent systematic reviews including several randomized controlled trials have concluded that silver diamine fluoride (SDF) shows potential as an effective agent for caries prevention and control in individuals with extreme caries risk.  We hypothesized that treatment of teeth with (SDF) before and after oral cancer irradiation will improve hardness and reduce the susceptibility of teeth to demineralization and RRC. The aim of this study is to evaluate the effects of SDF and other fluoride delivery systems on hardness of enamel and dentin exposed to cancer irradiation.

Methods
Extracted Molars and premolars were mounted in acrylic resin and polished to expose flat enamel and dentin surfaces. The teeth were divided into four groups with ten teeth in each group and treated as follows: no treatment control, treatment with SDF, MI Varnish and Cavity Shield. The teeth were then exposed to 2Gy five days per week for six weeks using an X-Rad 320ix Biological Irradiator. Fluoride treatments were repeated after irradiation.  Knoop hardness of enamel and dentin were measured before and after irradiation.   Thermal analysis of enamel and dentin was performed using TA Instruments Q2000 DSC in air.
Results and Conclusion
Treatment with SDF and MI Paste significantly increased hardness of non-irradiated dentin. Irradiation significantly reduced hardness of both enamel and dentin. Treatment of teeth with fluoride formulations after radiation partially restored the hardness of enamel and dentin. Irradiation of teeth for oral cancer treatment altered the thermal properties of dentin and enamel and reduced their response to remineralization with fluoride treatments.

  • Oral and Dental Health
  • Oral Medicine
  • Periodontics and Oral Hygiene
  • Oral Microbiology
  • Oral Oncology
  • Cosmetic Dentistry
  • Oral Cancer
  • Oral Problems
  • Dental Hygiene
  • Oral and Maxillofacial Surgery
  • Dental Implant Surgery