Title: The epidemiological studies of beta trace protein as an early predictor endogenous marker for renal damage

Biography:

Abstract

Chronic kidney disease (CKD) considered one of the most serious diseases that are strongly correlated with high morbidity and mortality. This study aimed to assess beta trace protein (BTP) via serum level measurement as an early predictor endogenous marker that response to renal damage or decrease in renal function. Serum level of creatinine and cystatin C were measured for comparative performance study. A case control study of 150 patients in two age groups: the pediatric group from 6 to less than 19 years old children, and the adult group from 19-70 years old. They were classified into three groups: 50 (29 males and 21 females) patients of type 1 and type 2 diabetes mellitus, 50 males renal transplant patients and 50 (28 males and 22 females) chronic kidney disease patients due to other than diabetes as an underlying cause. The results were compared with 50 (32 males and 18 females) apparently healthy used as controls. The results were revealed: Serum concentration of BTP was significantly increased (P < 0.05) in all patients groups when compared to control group, with a significant response concerning early stages of CKD It may be a useful and reliable serum marker for identifying the magnitude of renal dysfunction in patients with CKD and may have its place beside serum cystatin C and creatinine as an alternative endogenous marker of GFR.