Introduction: Hydrocephalus represents a significant burden of disease, with greater than 383,000 new cases annually worldwide. When considering the magnitude of this condition, a centralized archive on pertinent literature is of great clinical utility, and from a neurosurgical standpoint, the impact of hydrocephalus constitutes one of the most frequently treated conditions in the field. The focus of this study was to identify the top 100 journal articles specific to hydrocephalus utilizing bibliometric analysis.
Methods: Using the Journal of Citation Report database, ten journals were identified. A search was then performed on the Web of Science Core Collection using each journal name and the search term “hydrocephalus.” The results were then ordered by “Times Cited” and searched by the number of citations. The database contained journal articles from 1976-2021, and the following variables were collected for analysis: journal, article type, year of publication, and the number of citations. Journal articles were excluded if they had no relation to hydrocephalus, involved basic science research, or included animal studies.
Results: Ten journals were identified, using the above criteria, and a catalog of the 100 most cited publications in hydrocephalus literature was created. Articles were arranged from highest to lowest citation number, with further classification by journal, article type, and publication year. Articles were also distinguished by study type and further stratified by etiology. If etiology was not specified, studies were instead subcategorized by treatment type.
Conclusion: Through our analysis of highly cited journal articles focusing on different etiologies, and fields of surgical or medical management of hydrocephalus, we hope to elucidate important trends. By establishing the 100 most cited hydrocephalus articles, we contribute one source, stratified for efficient reference, to aid neurosurgeons’ and other potential learners’ research in hydrocephalus.

Background: Cerebral aneurysm healing is a dynamic process mediated by inflammation, ingrowth, and vessel wall remodeling. Monocyte chemotattractant protein 1(MCP-1) and osteopontin (OPN) have been identified separately as key mediators of the aneurysm healing process following coil embolization in the rodent model. The ability for protein coated coils to accelerate this process in currently unknown. 
Methods: We use a polymer (Poly [glycolide-co-caprolactone]) (Rao pharmaceuticals) (CG910) to test whether coils can be dual coated with active proteins with sequential reliable release.  Coils were coated with PLGA, CP910, and subsequently dipped with protein OPN (inner layer for delayed release) and MCP (outer layer for initial release). Release assays were utilized to measure protein elution from coils over time.  To test in vivofeasibility, coated coils were implanted into carotid aneurysms to determine effect on aneurysm healing. ARRIVE guidelines were followed for the study. ANOVA and student t-test was performed for assays with p<0.05.  
Results: In the in vitro studies, a significant amount of OPN and MCP release was measured early (within 2 days). Using a 200ug/uL solution of MCP-1 in PBS, we were able to show that CG910 coated coils provided the most effective release of MCP over time of the available polymers. Within the carotid aneurysm model, MCP and OPN release caused a significant degree of ingrowth (74 and 80%) compared to PLGA and CG910 alone (58 and 53%). To study mechanism, Nos3 and MMP9 were investigated, and both had significant increases for the OPN and MCP groups compared to other coils (p<0.001). A further analysis of proinflammatory markers Nox4 and NFkB showed increased overlap coefficients with CD31 for the OPN and MCP groups. To determine synergistic impact of dual coating, we measured ingrowth for MCP/OPN coils (63%) as well as overlap coefficients for Nox4 and NFkB with CD31. OPN staining was found primarily within the region of ingrowth whereas MCP staining was localized along the endothelium indicating variable release response in vivo. Conclusions: this study demonstrates that MCP-1 and OPN coated coils are viable and may promote early aneurysm healing. Dual coated coils may have synergistic benefit given different location of protein interaction measured in vivo. Further work is warranted to validate findings prior to advancement towards clinical trial.  

All the experts and all the psychiatrists in the medical environment know that a strong contingent of psychopaths begin their delinquent career as unbalanced to complete it, it is, however, a crucial question.from puffiness to delirious efflorescence and from level to level, like authentic schizophrenics.
Another point seems to insufficiently underlined, which testifies to the structural defect, to the psychopathic lack of organization. It is rare for one to die as a psychopath: after the classic turn of quarantine, what often dominates is chronic alcoholism, drug addiction, homelessness, for those who did not die prematurely by accident, overdose or alcoholic decompensation. Some find a less tragic outcome in a profession that resonates with their grandiose self, in a companionship with an older woman, both mothering and complacent about deviations or violence, having found, behind the rolling tatok of mechanics, the child B repair and then, some switch from rebellion against authority to the defense of small property and claim in the second part of their life what they had discovered in the first.
Dynamics and Treatement by psychologists , the addresses three problematics : first the question of the existence of a psychopathic malaise in today’s society characterized by the prevalence of the act and all powerful omnipotence of the act and the all powerful omnipotence on psychic intemalisation. Second, the serial killer and the fascination he inspires is addressed in a comparison between the United States and France and Morocco. Finally, the attempts to determine the principal characteristics. He considers essential to oppose clinical truth to the dual disorders of the serial killer and psychopathology its underlying stakes. Clinic, medico-legal and psychopathological, which has resulted in sterile “quarrels of experts”: opposing organized and disorganized serial killers, perverse and psychotic psychopaths, is not enough. In line with previous research aimed at an exploration of clinical criminology through psychoanalytic psychopathology, if they do not refer to extreme criminal situations, were nevertheless likely to facilitate the understanding of serial crimes.



Keywords: Psychopaths, Serial killers, Narcissistic perversion, Sexual perversion, Splitting of the Ego, Predation.

Children, teens, and young adults who identify as (Lesbian, Gay, Bisexual, Transgender or Queer plus (LGBTQ+) hitherto referred to as Queer, are at greater risk of struggling with mental health conditions, suicidality and post-traumatic stress disorder (PTSD) than their peers who identify as straight and cis-gendered.
Transgender youth face further disparities as they are twice as likely to experience depressive symptoms, seriously consider suicide, and attempt suicide compared to cisgender lesbian, gay, bisexual, queer and questioning youth.
For many LGBTQ+ people, socioeconomic and cultural conditions, discrimination, prejudice, denial of civil and human rights, harassment, and family rejection, can also lead to new or worsened symptoms, particularly for those with intersecting racial or socioeconomic identities.
Health disparities are common in the LGBTQ+ community because of the internalized homophobia amongst Queer people, perceived or experienced homophobia and ostracization, and surprisingly, lack of education particularly among clinicians and healthcare providers.
The process of coming out (realizing one’s sexual orientation or true gender and sharing it with the outside world) in a world that is still largely homophobic and unsupportive is responsible for a great majority of stress and mental health challenges experienced by queer persons.
What if Queer people did not ever have to “come out”? What if we rather create a world free of homophobia and judgment which in turn allows them to rather invite us into their world? What if their trauma and stressors never existed? Imagine all the heartaches and pain we could be saving them?
We shall discuss 10 ways in which we, particularly clinicians can become better allies for the Queer folk in our lives. We shall learn how to create safe spaces for them to in turn help decrease the health disparities and their mental health challenges.