Title: Impulse Control Disorders and other Hyperdopaminergic Behavioral Disorders in Parkinson's Disease

Biography:

Dr Krystkowiak has completed his neurology qualification in 1997 (University of Lille, France) then his PhD in 2003 (University of Paris-Saclay). He is Professor of neurology since 2007 at the University of Picardie, Amiens, France. He held academic positions such as Vice-President to the University Scientific Board, and as Vice-Dean of the Faculty of Medicine. He also served as Medical Director of Amiens University Hospital from 2015 to 2019. He joined Mediclinic Airport Road Hospital in 2019 then Yas Clinic Khalifa City in January 2022. He has published over 125 articles in international peer reviewed journals, mostly in the field of Parkinson’s disease and movement disorders.        

Abstract

Impulse control disorders (ICDs) mostly consist in pathological gambling, hypersexuality, compulsive eating, excessive buying. ICDs and other related behaviors, such as punding and dopamine dysregulation syndrome (DDS), are still underrecognized non-motor complications in Parkinson's disease (PD) even though recent studies suggest it could affect 25% of PD patients, with a negative impact on the quality of life (QoL) of both patients and caregivers.

All these impulse control behaviors (ICBs) are a range of behaviours linked by their reward-based, repetitive natures.

They can be precipitated by dopamine replacement therapy (DRT) even if other risk factors have been reported : individual’s predisposition (endophenotype and genetic susceptibility) and PD pathology as well. The main risk factors for ICBs are the use of dopamine agonists (DAs), male gender, young age, depression, smoking, drug abuse, family history of ICBs, Parkin mutation and single nucleotide polymorphism in D1, D2, and D3 dopamine receptors as well.

The nigrostriatal, mesocortical, and mesolimbic dopaminergic pathways play a crucial role in the pathogenesis of PD-ICBs as especially evidenced by functional imaging studies. The greater tonic release of dopamine creates a state of relative dopamine deficit and reduced reward sensation and impulsive behaviors.

Questionnaire for impulsive-compulsive disorders in PD is the most widely adopted screening tool for the detection of PD-ICBs.

Based on these data, a range of pharmacological and non-pharmacological management strategies have been tested in PD-ICBs, with varying success. The role of deep brain stimulation (DBS) and apomorphine in the treatment of ICBs is still uncertain.