Title: HYDROURETIC RENAL FUNCTION IN RATS WITH ACUTE RENAL FAILURE FOLLOWING INTAKE NATURAL ZEOLITES OR GALEGA ORIENTALIS PLANT POWDER

Biography:

The International Academy of Sciences of the High  School and Russian Academy of Natural Sciences, the academician of the International Academy of Sciences of ecological safety,   Dr.Sci.Biol., Professor, Head of Dept. of anatomy, physiology, and safety of life, Director of the scientific research institute of health and safety at Novosibirsk State Pedagogical University, the honored professor of Tuva State University. The foreign member of the American physiological society, a full member of the European Society of pediatrists-nephrologists, and the editorial member of seven scientific journals. In 1996 was included in the International biographic directory of famous scientists. He has over 800 publications that have been cited over 5900 times, and his publication H-index is 31.

Abstract

 To find out the possibility of using natural zeolites and plant resources to correct kidney functions in acute renal failure (ARF), two series of experiments were conducted on adult male Wistar rats. In each series, animals with experimentally induced ARF were divided into 2 groups. The first group consisted of animals with ARF who received standard feed, the second group included animals with ARF who received additives in addition to the feed in the form of a) powdered natural zeolite at the mass of 5% by weight of feed (first series, ARF + Z); b) Galega Orientalis plant powder (ARF + GO) in the amount of 2% by weight of feed (second series). In addition, a common control group (K) was organized, consisting of intact animals on a standard diet. Analysis of background urine samples in both series revealed the presence of polyuria in rats with ARF (control - 0.2±0.02; ARF - 0.3±0.04∆ ml/100g h), despite a significant decrease in GFR (control - 17.7±2.9; ARF - 6.8±1.0∆ ml/100g h). The diuretic reaction was probably due to a decrease in the water reabsorption (control – 99.2 ± 0.1; ARF – 95.6± 0.8∆%). In rats, after three days of per oral intaking zeolites, only a reduced level of relative reabsorption of fluid was observed compared to the control (97.2± 0.9∆%), while diuresis (0.2±0.1 ml/100g h) and GFR (15.0± 5.8 ml/100g h) did not differ from similar parameters of healthy animals. Against the background of taking the powder of the Galega Orientalis plant, only an increase in the volume of background diuresis was noted (0.5 ± 0.06∆ ml/100g h). After per oral intake of water load (5% of body weight), the level of diuresis in animals with ARF was 2 – 2.5 times lower than in the control group (K – 1.6 ± 0.3; ARF - 0.7± 0.3∆; ARF+ Z - 0.6± 0.3∆ ml/100g h), which was probably due to a reduced level of GFR (K – 20.3±3.1; ARF – 12.7±2.2∆; ARF+Z - 14.9±5.3 ml/100g h) and increased reabsorption of fluid (control – 91.7±1.1; ARF – 92.3±2.0; ARF+Z - 95.2±1.3Δ %), respectively. Intake of the Galega Orientalis plant powder did not give any significant differences in renal response compared to the ARF group. It can be concluded that natural zeolites caused an improvement in filtration and reabsorption processes in rats with acute renal failure, contributing to the normalization of the functional state of the kidneys. At the same time, the Galega Orientalis plant powder did not have a nephroprotective effect. _________________ Significant differences from rats with ARF and/or control.