Nora Awad Ali Alkudaisi is pursuing PhD in physics department at University of Strathclyde. Her doctoral research investigates the fluorescence properties of lysozyme gold nanocluster when protein structure is change. She holds a master’s degree in nanoscience from the University of Strathclyde, UK. She obtained her BA and works as a lecturer in Physics department at Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Abstract
Misfolded protein can lead to Amyloids which related to many diseases such as Alzheimer's, Parkinson's, Huntington's. Therefore, studying protein structure is vital to develop a treatment. Here, the lysozyme gold nanocluster (Lyz - AuNCs) is used to study protein folding/unfold. The fluorescence intensity of gold nanocluster is study as function of increasing temperate, Urea and Sodium Dodecyl Sulphate (SDS). It is known that Urea and SDS can lead to fold/ unfold the native (Lyz). The effect of temperature on Bovine serum albumin encapsulated gold nanocluster (BSA – AuNCs) has been studied.