BodyThe lecture concerns the own newly developed category of nanostructured biological-engineering materials. The hybrid technology using selective laser sintering SLS with the nanocoatings by atomic layers deposition ALD method inside the micropores of the skeletons improving the nesting and proliferation of living cells were applied. As input material alternatively powders of both pure titanium and Ti6Al4V alloy were used. The TiO2 and Al2O3 coatings were deposited inside micropores using the ALD method and hydroxyapatite with the sol-gel submersion coating method. The properties and structure were investigated using advanced HRTEM research. Due to the presence of deposited TiO2 and Al2O3 nanostructured coatings, conditions of nesting and proliferation of live cells of the hFOB 1.19 (Human ATCC - CRL - 11372) osteoblasts on the surface of micropores are significantly improved. The nanostructured hydroxyapatite coatings after a relatively short time will biodegrade, and living cells will be in contact with a metal skeleton that is not covered by any coating. Therefore it is inapplicable for long-term implants. The performed research fully confirmed the original idea of the microporous implant-scaffolds production as a new type of medical devices.

     The impact of natural products on drug discovery pipelines keep kindling our interest in structurally unpredictable low-molecular-weight biomolecules as a promising source of pharmaceutical leads. Meanwhile, scientists are frequently frustrated by re-isolations of known compounds from new organism collections since countless natural products have been identified since Serturner’s characterization of morphine in 1806. To address this frustration, the affordability and chemical space expansion of minor new natural products become a great concern, and chemical synthesis has been performed to produce organism-originated complex molecules and natural product-like compounds with privileged scaffolds. To add more skills to the existing arsenal of searching for highly-valued new chemicals like drug leads, this talk will present the discovery and biosynthesis of bioactive secondary metabolites from symbionts, some of which are evidenced to be evolutionally advanced owing to their non-stop interaction with multicellular hosts such as plants, insects and fishes. This presentation will be focused on the structure characterization and biosynthetic mechanism of bioactive secondary metabolites with unprecedented carbon skeletons from the cultures of symbiotic microorganisms such the marine-derived Curvularia sp. (see Image).

Magnesium alloys with their high specific strength and low weight are used as structural materials in different applications. They have suitable mechanical and excellent damping. Magnesium wrought alloys, such as for instant AZ31, are needed for applications where their weight is important. In the accumulative roll bonding (ARB) technique, stacking of a material and conventional roll-bonding are repeated in the process. Samples for further studies were cut from the sheets so that the longer axis was either parallel (L samples) or perpendicular (T samples) to the rolling direction [1].

Tensile tests were performed at temperatures ranging from room temperature up to 300 °C. Different results were obtained for L and T samples. This anisotropy decreases with increasing number of rolling passes and increasing deformation temperature.

The amplitude dependent internal friction was measured at room temperature. Anelastic planar anisotropy of internal friction was observed; the logarithmic decrement was higher in rolled sheets cut perpendicular to the rolling direction than that in the samples where the longer axis was parallel to the rolling direction.

The linear thermal expansion of samples was measured in the temperature range from room temperature up to 400 °C. Planar anisotropy of the thermal expansion was found.

Thermal diffusivity and thermal conductivity were measured after 1 and 2 passes through the rolling mill. Thermal diffusivity was measured with the laser-flash method in the temperature range between 20 and 350 °C. Thermal conductivity depends on the number of rolling passes. Results are discussed in terms of microstructure and texture of materials prepared with ARB technique.

Renewable Resources.Post-doctorate, Department of Biological Sciences, University of Alberta, Edmonton, Canada (2005-2008).Post-doctorate, Ecosystem Science and Management, University of Northern British Columbia, Prince George, Canada (2004).Post-doctorate, Department of Environmental Sciences, University of California, Riverside, USA (2003-2004).Ph.D., Department of Environmental Sciences, University of California, Riverside, USA (2001-2003) and University of Agriculture, Faisalabad, Pakistan (1999-2000).M.Sc. (Hons), University of Agriculture, Faisalabad, Pakistan (1989-1992).B.Sc. (Hons), University of Agriculture, Faisalabad, Pakistan (1985-1989)